نتایج جستجو برای: bad gene
تعداد نتایج: 1170207 فیلتر نتایج به سال:
stress is one of the effective factors in the development of depressive disorders that performs some parts of its effects by affecting hippocampus. since doxepin has been shown to have neuroprotective effects, in this study, we focused on the effects of doxepin on the expression of involved genes in neuronal survival and plasticity in the rat hippocampus following chronic stress. male wistar ra...
Esophageal cancer (EC) is the eighth most prevalent and sixth leading cause of cancer-related mortality worldwide. As an antiapoptotic a proapoptotic protein, respectively, survivin Bad play important role in carcinogenesis human cancers including EC. However, regulatory relationships between them remain unclear. We sought to investigate effects knockdown overexpression on expression gene, cell...
UNLABELLED Epstein-Barr virus (EBV) is a human gammaherpesvirus associated with a variety of tumor types. EBV can establish latency or undergo lytic replication in host cells. In general, EBV remains latent in tumors and expresses a limited repertoire of latent proteins to avoid host immune surveillance. When the lytic cycle is triggered by some as-yet-unknown form of stimulation, lytic gene ex...
In this paper we describe a method for generating high school timetables using an Evolutionary Algorithm (E.A.) with a new set of genetic operators inspired on the Infected Genes Evolutionary Algorithm [14]. We show that widening region of infection considered in [7] leads to a very significant increase in the performance of the E.A.. Comparative tests between the E.A. with and without the impr...
In this paper we describe a method for generating high school timetables using an Evolutionary Algorithm (E.A.) with a new set of genetic operators inspired on the Infected Genes Evolutionary Algorithm (Tavares, 99). We show that widening region of infection considered in (Fernandes, 99) leads to a very significant increase in the performance of the E.A.. Comparative tests between the E.A. with...
The malignant transformation of normal cells is caused in part by aberrant gene expression disrupting the regulation of cell proliferation, apoptosis, senescence and DNA repair. Evidence suggests that the Bcl-2 antagonist of cell death (BAD)-mediated apoptotic pathway influences cancer chemoresistance. In the present study, we explored the role of the BAD-mediated apoptotic pathway in the devel...
utrition and cell death are integrated in a single mitochondrial complex, according to Nika Danial, Stanley Korsmeyer (Harvard Medical School, Boston, MA), and colleagues. The complex was discovered after gel filtration of the pro-apoptotic BAD protein, and contains BAD, a phosphatase, kinase, and kinase-anchoring protein directed at BAD, and glucokinase. In cells lacking BAD, the complex falls...
Purpose: Despite initial sensitivity to chemotherapy, ovarian cancers (OVCA) often develop drug-resistance, which limits patient survival. Using specimens and/or genomic data from 289 patients and a panel of cancer cell lines, we explored genome-wide expression changes that underlie the evolution of OVCA chemo-resistance and characterized the BCL2 antagonist of cell death (BAD) apoptosis pathwa...
Purpose: Despite initial sensitivity to chemotherapy, ovarian cancers (OVCA) often develop drug-resistance, which limits patient survival. Using specimens and/or genomic data from 289 patients and a panel of cancer cell lines, we explored genome-wide expression changes that underlie the evolution of OVCA chemo-resistance and characterized the BCL2 antagonist of cell death (BAD) apoptosis pathwa...
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