BACKGROUND Cryptococcal meningoencephalitis is a lethal infection with relatively few therapeutic options. The optimal dosage of liposomal amphotericin B (LAmB) alone or in combination with flucytosine is not known. METHODS A murine model of cryptococcal meningoencephalitis was used. The fungal density in the brain was determined using quantitative cultures. Pharmacokinetic-pharmacodynamic re...

Lamb wave time reversal method is a new and tempting baseline-free damage detection technique for structural health monitoring. With this method, certain types of damage can be detected without baseline data. However, the application of this method to thin-wall structures is complicated by the existence of at least two Lamb wave modes at any given frequency, and by the dispersion nature of the ...

Our laboratory has been utilizing the Escherichia coli outer membrane protein LamB to study the mechanism of protein localization. Various lines of evidence suggest that, in addition to a signal sequence, regions within the mature protein are required for efficient localization. In particular, studies using LamB-LacZ hybrid proteins have identified regions between amino acids 27 and 49 of matur...

| Damage detection using guided Lamb waves is an important tool in Structural health Monitoring. In this paper, we outline a method of obtaining Lamb wave modes in composite structures using two dimensional Spectral Finite Elements. Using this approach, Lamb wave dispersion curves are obtained for laminated composite structures with different fibre orientation. These propagating Lamb wave modes...

We study the survival of a single diffusing lamb on the positive half line in the presence of N diffusing lions to the right of the lamb and a haven at x = 0. If the lamb reaches this haven before meeting any lion, the lamb survives. We investigate the survival probability of the lamb, SN (x,L), as a function of N and the respective initial positions of the lamb and the lions, x and L. We deter...

Signal sequences function in protein targeting to and translocation across the endoplasmic reticulum membrane. To investigate the structural requirements for signal sequence function, chimeras of the Escherichia coli LamB signal peptide and prolactin were prepared. The LamB signal peptide was chosen by virtue of the extensive biophysical and biological characterization of its activity. In vitro...

The appearance of newly induced LamB protein at the cell surface of Escherichia coli was followed topographically by immuno-electron microscopy. LamB protein was induced in E. coli wild-type or lac-lamB cells for a short period of time (4 to 6 min), such that the overall level of LamB protein in induced cells was at least twofold higher than that in uninduced cells. Antibodies bound to LamB pro...

a four- year-old moghanian breed ewe was admitted to the large animal veterinary clinic, university of tabriz due to dystocia. during obstetrical examination, it was revealed that the cervix has been closed firmly and vagina protruded about 5 cm through the vulva (vaginal prolaps). based on clinical findings and for saving the dam and lamb(s), the cesarean section was done. a normal alive femal...

For this study, 24 Bakhtiari sheep were selected and divided into four age groups: 1-10 days, 5-8 months, 1-2 years and 3 years and more. In each age group, six animals (3 each sex) were used. The specimens of eight different skin regions were collected. They were fixed in 10% formaldehyde solution and processed through routine paraffin embedding, cut at 5-7 μ and stained with H&E, Masson trich...