Vault is the largest nonicosahedral cytosolic nucleoprotein particle ever described. The widespread presence and evolutionary conservation of vaults suggest important biologic roles, although their functions have not been fully elucidated. X-ray structure of vault from rat liver was determined at 3.5 Å resolution. It exhibits an ovoid shape with a size of 40 × 40 × 67 nm(3). The cage structure ...

Vaults are cytoplasmic ribonucleoprotein organelles that are highly conserved among diverse eukaryotic species. Their mass (12.9 MDa), diameter (26-35 nm) and shape (two halves, each with eightfold radial symmetry) have recently been determined and are similar to those ascribed to the central plug (or transporter) of the nuclear pore complex (NPC). The size and eightfold symmetry of the vault p...

Vaults may contribute to multidrug resistance by transporting drugs away from their subcellular targets. To study the involvement of vaults in the extrusion of anthracyclines from the nucleus, we investigated the handling of daunorubicin by drug-sensitive and drug-resistant non-small lung cancer cells, including a green fluorescent protein (GFP)-tagged major vault protein (MVP)-overexpressing t...

Vault is one of the artistic gymnastics events, either for males and females competitions. Since 2001, vault regulations include an approach running of 25 m, a springboard and a rectangular table with a surface measuring 1.20 m x 0.95 m.  e table height is di€ erent among males (1.35 m), females (1.25 m) and juniors categories (1.15 m).  e competition regulations require from a gymnast to per...

Vaults are cytoplasmic ribonucleoprotein particles composed of three proteins (MVP, TEP1, vPARP) and vault‑associated RNAs (vRNAs). Although the cellular functions of vaults remain unclear, vaults are strongly linked to the development of multidrug resistance (MDR), the major obstacle to the efficient treatment of cancers. Available published data suggest that vaults and their components are fr...

A 104-kD protein was coimmunoprecipitated with the estrogen receptor from the flowtrough of a phosphocellulose chromatography of MCF-7 cell nuclear extract. mAbs to this protein identified several cDNA clones coding for the human 104-kD major vault protein. Vaults are large ribonucleoprotein particles of unknown function present in all eukaryotic cells. They have a complex morphology, including...

User privacy and template security are major concerns in the use of biometric systems. These are serious concerns based on the fact that once compromised, biometric traits can not be canceled or reissued. The Fuzzy Vault scheme has emerged as a promising method to alleviate the template security problem. The scheme is based on binding the biometric template with a secret key and scrambling it w...

Vaults are very large oligomeric ribonucleoproteins conserved among a variety of species. The rat vault 3D structure shows an ovoid oligomeric particle, consisting of 78 major vault protein monomers, each of approximately 861 amino acids. Vaults are probably the largest ribonucleoprotein structures in eukaryote cells, being approximately 70 nm in length with a diameter of 40 nm--the size of thr...

A cross-sectional study of one thousand and sixty-five children (508 boys and 557 girls) from the Watertown School System was done in order to determine whether there is a relationship between airway obstruction, palatal vault formation and malocclusion. The age range was 5 to 12 years old with a mean age of 8.5 years. Breathing pattern was based on the lip competency (seal) of each individual....