Background: Breast cancer is one of the most prevalent cancers among women. Common cancer treatment methods are not effective enough, and there is a need for a more efficient treatment procedure. Cancer vaccine is a novel immunotherapy method that stimulates humoral and/or cellular immunity against cancer. Placenta-specific protein 1 (PLAC1) is a cancer/testis antigen, prevalent in breast cance...

Therapeutic cancer vaccines based on the abnormal glycans expressed on cancer cells, such as the globo H antigen, have witnessed great progress in recent years. For example, the keyhole limpet hemocyanin (KLH) conjugate of globo H has been on clinical trials as a cancer vaccine. However, such vaccines have intrinsic problems, such as inconsistence in eliciting T cell-mediated immunity in cancer...

Cancer Immunotherapy In article number 2301789 by Qiuyun Li, Gang Ji, Guodong Yang, and co-workers, a modular hydrogel based vaccine system is developed. combination with sonodynamic therapy, the efficiently inhibits tumor growth metastasis via diverting TdLN metastatic cancer to hydrogel, killing trapped cells, eliciting prolonged powerful immunotherapy in sequential orchestrated manner.

background: cancer registries are important infrastructure for cancer control programs. however most developing countries lack population based cancer registry. in iran there cancer incidence is estimated based on pathology-based cancer registry. in this study we evaluated results of the nationwide pathology-based cancer registry in iran. materials and methods: we compared age-standardized inci...

Objective(s): Blocking of vascular endothelial growth factor (VEGF) plays a pivotal role in inhibition of metastasis and is a target for development of anti-angiogenic agents. In this study, a peptide-based vaccine was designed and its potential for induction of humoral immune responses, generation of neutralizing antibodies, inhibition of tumor growth and metastasis w...

In 2006, the U.S. Food and Drug Administration (FDA) approved the first vaccine for prevention of cervical cancer based on the molecular biology of the disease. Gardasil (quadrivalent human papillomavirus [HPV] [types 6, 11, 16, and 18] recombinant vaccine, Merck & Co., Inc., Whitehouse Station, NJ) combats the common types of HPV responsible for cervical cancer precursor lesions. This article ...

BACKGROUND Despite recent progress with novel chemotherapy regimens, pancreatic ductal adenocarcinoma remains the fourth leading cause of cancer death in the United States. Innovative approaches to treatment of this disease are needed to accelerate progress. METHODS A review was conducted of the results of 2 pancreatic cancer vaccine programs with results that have shown promise in early-phas...