BACKGROUND Several surgical options for the reconstruction of massive bone defects have been described and include biologic methods with autografts and allografts, and the use of tumor endoprostheses (total femoral replacement, TFR). Several types of modular TFR are available, but nevertheless unpredictable outcomes and high complication rates have been described from most authors. The present ...

Several clinical trials have demonstrated that some patients with chronic myeloid leukemia in chronic phase (CML-CP) who achieve sustained deep molecular responses on tyrosine kinase inhibitor (TKI) therapy can safely suspend therapy and attempt treatment-free remission (TFR). Many TFR studies to date have enrolled imatinib-treated patients; however, the feasibility of TFR following nilotinib o...

Coated vesicles were purified from human placenta by sedimentation, isopycnic centrifugation, and gel filtration. Quantitative Western blotting of the endogenous transferrin receptor (tfR) demonstrated the presence, on average, of roughly one receptor per vesicle. TfR appeared undersaturated with transferrin. After solubilizing vesicles in nonionic detergent, we looked for evidence of tfR inter...

Objectives Total flavones from Rhododendron simsii Planch. (TFR) are the effective part extracted from the flowers of Rhododendron simsii Planch. and have obvious protective effects against cerebral ischemic or myocardial injuries in rabbits and rats. However, their mechanism of cardioprotection is still unrevealed. Therefore, the present study was designed to investigate the effect of TFR on m...

The transferrin receptor (TfR) mediates the uptake of transferrin (Tf)-bound iron from the plasma into the cells of peripheral tissues. The TfR continuously recycles between the plasma membrane and early/recycling endosomes. TfR expression is tightly controlled by the intracellular iron concentration through the regulation of TfR mRNA stability. However, much less is known about the mechanism b...

Follicular regulatory T cells (TFR) have been extensively characterized in mice and participate in germinal center responses by regulating the maturation of B cells and production of (auto)antibodies. We report that circulating TFR are phenotypically distinct from tonsil-derived TFR in humans. They have a lower expression of follicular markers, and display a memory phenotype and lack of high ex...

Transferrin receptor (TfR) has been shown to be significantly overexpressed in different types of cancers. We discovered TfR as a target for gambogic acid (GA), used in traditional Chinese medicine and a previously undiscovered link between TfR and the rapid activation of apoptosis. The binding site of GA on TfR is independent of the transferrin binding site, and it appears that GA potentially ...

Understanding emerging patterns of low fertility in middle-income countries is of essential importance. We demonstrate that the use of the P/F Brass methods in Brazil to adjust for a presumed underreporting of births has the potential to overestimate the country’s 2010 TFR by about 8%. Our preferred fertility-register-based estimate is 1.76, substantially lower the officially reported 1.90. Thi...

We investigate the amount of scatter in the Tully-Fisher relation (TFR) when using optical long-slit H rotation curves to determine the velocity widths of spiral galaxies. We study a sample of 25 galaxies in the Coma region of the sky which were shown in Bernstein et al. (1994) to exhibit an extraordinarily low scatter of 0.10 mag RMS in the I magnitude vs 21-cm width TFR. Using the same I magn...

In complex machines, the failure signs of an early bearing damage are weak compared to other sources of excitations (e.g. gears, shafts, rotors, etc.). The task of emphasizing the failure signs is complicated by the fact that changes in operating conditions influence vibrations sources and change the frequency and amplitude characteristics of the signal, making it non-stationary. As a result, a...