نتایج جستجو برای: bax expression
تعداد نتایج: 877301 فیلتر نتایج به سال:
Background: Apoptosis is an essential physiological process to maintain immune homeostasis. T-cell incorrect apoptosis appears to be involved in chronic inflammatory diseases such as inflammatory bowel disease (IBD). The aim of this study was to evaluate the Bcl2/BAX genes expression ratio in patients with IBD (Crohn’s disease and ulcerative colitis) compared to healthy persons. Materials and M...
The Effect of Cadmium on Apoptotic Genes mRNA Expression of Bax and Bcl-2 in Small Intestine of Rats
Background: Cadmium is a potent toxicant and carcinogenic in human and experimental animals. The evidence indicates that cadmium induces aberrant gene expression, inhibition of DNA damage repair, and apoptosis. In this study, we investigated the effects of IP (intraperitoneal) injection of cadmium on mRNA levels expression of Bcl-2 and Bax genes in rat small intestine. <s...
Objective: Some previous studies have shown that protective effect of caffeine against induction of apoptosis through in the regulation of pro- and anti-apoptotic proteins. Therefore, the aim of this study was to investigate the effects of chronic caffeine administration on the interactions among of Bax and Bcl-2 proteins in the cardiac tissue of induced type two diabetic rats. Methods: In exp...
molecular mechanisms of luteolin induced growth inhibition and apoptosis of human osteosarcoma cells
luteolin is a flavone in medicinal plants as well as some vegetables and spices. it is a natural anti-oxidant with less pro-oxidant potential but apparently with a better safety profile. the purpose of this study was to investigate the molecular mechanism of luteolin-mediated apoptosis of mg-63 human osteosarcoma cells. mtt assay kit was employed to evaluate the effects of luteolin on mg-63 cel...
THE EFFECT OF A PERIOD AEROBIC AND INTERVAL TRAINING ALONG WITH ASTAXANTHIN SUPPLEMENTATION ON EXPRESSION BAD, BAX, BCL2 GENES IN KIDNEY TISSUE RATS TYPE 2 DIABETES
Introduction: Cryptorchidism has been proved to cause apoptosis in germ cells in respond to changes in the stimulation levels of specific physiological events. The purpose of this study was to determine whether treatment of bilateral cryptorchidism was associated with alterations in testicular gene expression. Methods: To induce bilateral cryptorchid model, immature mice were anesthetized and a...
Introduction: This study aimed to compare the response of liver tissue BAX and BCL-2 gene expression to aerobic training with L-carnitine supplementation in rats intoxicated by Boldenone. Material and Methods: In this experimental study, 30 male Wistar rats, aged 12 weeks (weight 195±7.94 g) were randomly divided into five groups: control, no-treatment, boldenone (5 mg/kg), L-carnitine (100 mg...
Introduction: Breast cancer is the most common metastatic malignancy and the second leading cause of death in women. Recently, extremely low-frequency electromagnetic fields (ELF-EMFs) seem to modulate the rate of proliferation and enhance apoptosis and are considered as an emerging approach to cancer therapy. Despite recent success in the electromagnetic fields, the results are still neither d...
Background: Imbalance of apoptotic factors plays important role in pathogenesis of diabetes. Considering the role of curcumin supplementation and high-intensity interval training (HIIT) on these factors, the aim of this study was to investigate effects of four weeks of HIIT with curcumin supplementation on Bax and Bcl-2 gene expression in the soleus muscle of diabetic rats. Methods: Present st...
stress is one of the effective factors in the development of depressive disorders that performs some parts of its effects by affecting hippocampus. since doxepin has been shown to have neuroprotective effects, in this study, we focused on the effects of doxepin on the expression of involved genes in neuronal survival and plasticity in the rat hippocampus following chronic stress. male wistar ra...
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