Despite aggressive treatment with radiation and chemotherapy, recurrence of glioblastoma multiforme (GBM) is inevitable. The objective of this study was to show that the blood-brain barrier (BBB), through a combination of tight junctions and active efflux transporters in the brain microvasculature, can significantly restrict delivery of molecularly targeted agents to invasive glioma cells. Tran...

OBJECT The blood-brain barrier (BBB) limits the intracerebral penetration of drugs and brain tumor treatment efficacy. The effect of ultrasound-induced BBB opening on the intracerebral concentration of temozolomide (TMZ) and irinotecan (CPT-11) was assessed. METHODS This study was performed using 34 healthy New Zealand rabbits. Half had unilateral BBB opening, and half served as controls. Sonic...

BACKGROUND Blood brain barrier (BBB) permeability plays an important role in the brain impairments. The barrier is composed of endothelium cells, due to the presence of tight junctions that connect endothelium cells. The failure of BBB function has triggering chronic or acute seizures through brain inflammation and BBB permeability. Seizure induces vasodilation, BBB leakage and up-regulation of...

Of 50 consecutive patients with bundle branch block (BBB) complicating acute antero-septal infarction, 37 died in hospital. Patients with BBB of delayed onset or BBB of short duration had a significantly lower mortality. His bundle recordings were made in 35 patients without pulmonary edema or shock at the time of appearance of BBB. Thirteen of 16 patients with prolonged H-V intervals died comp...

Diabetes is a systematic metabolic disease, which often develops a number of well-recognized vascular complications including brain complications which may partly result from the dysfunction of blood-brain barrier (BBB). BBB is generally considered as a mechanism for protecting the brain from unwanted actions resulting from substances in the blood and maintaining brain homeostasis via monitorin...

Blood-brain barrier (BBB) dysfunction is a potential mechanism involved in progressive striatal damage induced by the mitochondrial excitotoxin, 3-nitropropionic acid (3-NP). After activation by proteases and free radicals, matrix metalloproteinases (MMPs), particularly MMP-9 and -2, can digest the endothelial basal lamina leading to BBB opening. Using CD-1 mice, we show that MMP-9 expression b...

Of 50 consecutive patients with bundle branch block (BBB) complicating acute antero-septal infarction, 37 died in hospital. Patients with BBB of delayed onset or BBB of short duration had a significantly lower mortality. His bundle recordings were made in 35 patients without pulmonary edema or shock at the time of appearance of BBB. Thirteen of 16 patients with prolonged H-V intervals died comp...

The blood-brain barrier (BBB) transport of oxycodone was studied in rats. Microdialysis probes were inserted into the striatum and vena jugularis. Ten animals were given a bolus dose followed by a 120-min constant rate infusion to study the steady-state concepts of oxycodone BBB equilibration. Another 10 animals were given a 60-min constant rate infusion to study the rate of equilibration acros...

Of 50 consecutive patients with bundle branch block (BBB) complicating acute antero-septal infarction, 37 died in hospital. Patients with BBB of delayed onset or BBB of short duration had a significantly lower mortality. His bundle recordings were made in 35 patients without pulmonary edema or shock at the time of appearance of BBB. Thirteen of 16 patients with prolonged H-V intervals died comp...

The blood-brain barrier (BBB) impedes the influx of intravascular compounds from the blood to the brain. Few blood-borne macromolecules are transferred into the brain because vesicular transcytosis in the endothelial cells is considerably limited and the tight junction is located between the endothelial cells. At the first line of the BBB, the endothelial glycocalyx which is a negatively charge...