Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype, and fewer than half of patients are cured with standard first-line therapy. To improve therapeutic options, better animal models that accurately mimic human DLBCL (hDLBCL) are needed. Canine DLBCL, one of the most common cancers in veterinary oncology, is morphologically similar to hDLBCL and is treated using similar che...

Inactivation of p53, themaster regulator of cellular stress and damage signals, often allows cells that should die or senesce to live. Loss of Dicer, an RNase III–like enzyme critical in microRNA biogenesis, causes embryonic lethality and activation of the p53 pathway. Several nonhematopoietic cell types that contain inactivated p53 have been shown to surviveDicerdeletion, suggesting that p53 l...

Leukemic B-cell chronic lymphoproliferative disorders (B-CLPD) are a relatively heterogeneous group of diseases, all of which exhibit a clonal expansion of mature-appearing B-lymphoid cells in the peripheral blood (PB). Both primary leukemias and the leukemic phase of primary lymphomas are included in this category (1). Among the primary B-cell leukemias, chronic lymphocytic leukemia (CLL), pro...

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype, and fewer than half of patients are cured with standard first-line therapy. To improve therapeutic options, better animal models that accurately mimic human DLBCL (hDLBCL) are needed. Canine DLBCL, one of the most common cancers in veterinary oncology, is morphologically similar to hDLBCL and is treated using similar che...

OBJECTIVE Little is known about the role(s) B cells play in obesity-induced metabolic dysfunction. This study used a mouse with B-cell-specific deletion of Id3 (Id3(Bcell KO)) to identify B-cell functions involved in the metabolic consequences of obesity. APPROACH AND RESULTS Diet-induced obese Id3(Bcell KO) mice demonstrated attenuated inflammation and insulin resistance in visceral adipose ...

Subependymoma is a rare benign tumor of the ventricular system. It was described as a distinct entity by Scheinker in 1945. The fourth ventricle is the most common location. Many cases are asymptomatic and discovered at autopsy. Symptomatic cases often present with hydrocephalus.We present two cases of subependymoma located in lateral ventricles. Case 1 was a 69-year-old male with non-Hodgkin's...

We describe 9 well-characterized cases of B-cell non-Hodgkin lymphoma (NHL) that showed aberrant expression of T-cell–associated antigens by 2-color flow cytometry. Cases were as follows: chronic lymphocytic leukemia/small lymphocytic lymphoma, 4; follicle center cell lymphoma, 2; mantle cell lymphoma, 1; and diffuse large B-cell lymphoma, 2. CD2 was the most commonly expressed antigen (5 cases...

non-hodgkin lymphoma (nhl) is one of the masquerade syndromes of malignant melanoma that can occur with two main patterns of presentations in the eye: metastatic involvement of uveal tract, and primary involvement of retina. we report ophthalmic, imaging and histopathological findings in the first case diagnosed as primary choroidal nhl without central nervous system or systemic involvement. a ...

Objective(s): To validate the reliability of nuclear medicine physicians in diagnosing lymphoma using positron emission tomography/computed tomography using 2-deoxy-2-[18F]fluoro-D-glucose (FDG-PET/CT) and to determine findings that reliably suggest lymphoma.Methods: Seventy patients suspected of having lymphoma using FDG-PET/CT were enrolled in this retrospective study. Two nuclear medicine ph...