Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. HLA-DRB1*15 and HLA-DRB1*17-bearing haplotypes and interactions at the HLA-DRB1 locus increase risk of MS but it has taken large samples to identify resistance HLA-DRB1 alleles. In this investigation of 7,093 individuals from 1,432 MS families,...

Cohabitation for 14 days with Ehrlich tumor-bearing mice was shown to increase locomotor activity, to decrease hypothalamic noradrenaline (NA) levels, to increase NA turnover and to decrease innate immune responses and decrease the animals' resistance to tumor growth. Cage mates of a B16F10 melanoma-bearer mice were also reported to show neuroimmune changes. Chemosignals released by Ehrlich tum...

PURPOSE Resistance to antiangiogenic therapy is an important clinical problem. We examined whether resistance occurs at least in part via reversible, physiologic changes in the tumor, or results solely from stable genetic changes in resistant tumor cells. EXPERIMENTAL DESIGN Mice bearing two human RCC xenografts were treated with sorafenib until they acquired resistance. Resistant 786-O cells...

Pile foundation systems are used in India many projects such as metro and railways, flyovers, multi-story buildings. The pile transfers superstructure load to the substructure, i.e. rock layers by means of skin resistance end-bearing resistance. In this study, an attempt is made observe performance socketed piles soft rock. A series small-scale model laboratory studies have been conducted using...

BACKGROUND The two main mechanisms of resistance to EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) are the occurrence of T790M secondary mutation in the kinase domain of EGFR and MET amplification. The aim of the present study was to test whether early changes of 18F-fluorodeoxyglucose (18F-FDG) uptake in animal models bearing erlotinib-resistant NSCLC may have dif...

The amount of antibiotics needed to counteract frequent piscirickettsiosis outbreaks is a major concern for the Chilean salmon industry. Resistance to antibiotics may contribute to this issue. To understand the genetics underlying Piscirickettsia salmonis-resistant phenotypes, the genome of AY3800B, an oxytetracycline-resistant isolate bearing a multidrug resistance plasmid, is presented here.

SUMMARY Active and passive immune resistance to implanted syn geneic sarcoma cells was expressed more effectively in vis ceral organs reached by intravascular implantation than in i.m. and s.c. implantation sites. Passive transfer of serum from tumor-cured as well as tumor-bearing donors gave resistance to unsensitized sublethally radiated recipients partially restored with transferred normal l...