SNEDDS merupakan campuran isotropik yang terdiri dari obat, surfaktan, ko-surfaktan dan minyak. Pengembangan optimasi formulasi tepat diperlukan untuk meminimalisir waktu, biaya, serta menjamin optimal. Tujuan penulisan artikel ini adalah menjelaskan aplikasi simplex lattice design (SLD) box behnken (BBD) dalam SNEDDS. Metode digunakan menyusun review yaitu teknik studi pustaka dengan mencari l...

BACKGROUND The periplasmic overexpression of recombinant human interferon beta (rhIFN-β)-1b using a synthetic gene in Escherichia coli BL21 (DE3) was optimized in shake flasks using Response Surface Methodology (RSM) based on the Box-Behnken Design (BBD). OBJECTIVES This study aimed to predict and develop the optimal fermentation conditions for periplasmic expression of rhIFN-β-1b in shake fl...

Amaranthus Tricolor L. (red amaranth) and Viridis (Green are Amaranthaceae members, widely cultivated in Asia consumed as a leafy vegetable many parts of the world. This study deal with nutritional functional, biochemical characterization A. viridis . Single-factor experiments Box Behnken Design (BBD) were used to optimize extraction process for phenolic compound from The BBD shows that 11.87mg...

background cadmium is a toxic metal that occurs naturally in the environment and is considered as a pollutant emanating from industrial and agricultural sources. biosorption is a very simple and cheap technique for removal of metal pollutants from aqueous samples. objectives in this study, removal of cadmium from aqueous solutions using c. colocynthis fruit powder was studied. materials and met...

Ultrasonic nanocrystal surface modification (UNSM) technology was applied to the surfaces of specimens additively manufactured by powder bed fusion (PBF). The changes in roughness and hardness due UNSM were set as objective functions, optimal conditions for main parameters derived through response method (RSM) Box–Behnken design (BBD). Regression analysis-based mathematical models predicting ar...

The marine environment plays a vital role in producing valuable natural products for biomedical and pharmaceutical research. pigment is one of the bioactive molecules derived from bacteria. strain SB2 was isolated saltern areas Marakanam to produce yellow pigment, round, smooth colonies on selective media. opted out further studies based its production (1.68 mg l-1). incubation period, pH, temp...

BACKGROUND The use of medicinal plants has been reported throughout human history. In the fight against illnesses, medicinal plants represent the primary health care system for 60 % of the world's population. Flavonoids are polyphenolic compounds with active anti-microbial properties; they are produced in plants as pigments. Quercetin, myricetin, and rutin are among the most well-known and prev...

conclusions it can be concluded that the rsm is an effective method for the optimization of recombinant protein expression using synthetic genes in e. coli. results the proposed optimum fermentation condition consisted of 7.81 g l-1 glucose, od 600 nm prior induction 1.66 and induction temperature of 30.27°c. the model prediction of 0.267 g l-1 of rhifn-β and 0.961 g l-1 of acetate at the optim...

Heavy metals adsorption by adsorbents prepared from natural materials is a low-cost effective method for their removal aqueous environments. This study aims to assess the applicability of orange zest biochar adsorb divalent copper (cupric chloride) its solution maximizing capacity using feed-forward back-propagation neural network (FFBPNN)–Box–Behnken design (BBD) modelling. BBD modelling predi...