an ion chromatography (ic) method for simultaneous determination of benzoic, salicylic and sorbic acids was developed. in this method the samples were purified by solid-phase extraction. the analytes were then eluted with methanol from c18 cartridge. the separation was performed on ion-exclusion column by an isocratic elution with 0.25 mmol /l sulfuric acid solution containing 20% (v/v) acetone...

In most laboratory mammals benzoic acid is converted into hippuric acid and benzoyl glucuronide (see Williams, 1959), except for the cat, which seems to produce only hippuric acid (Robinson & Williams, 1958, and unpublished data). Jaffe (1877) showed that benzoic acid was converted in hens into ornithuric acid, and benzoyl glucuronide has also been found to be a metabolite of benzoic acid in he...

The effect of substituents on the acidity benzoic acids and anilines has been organized in grids to demonstrate inductive resonance effects. relation between structure pKa is emphasized by a new educational process: Search-Organize-Predict (SOP) procedure.

The extensive investigations on the conjugation of benzoic acid, since Wohler’s discovery in 1824 of the synthesis of hippuric acid by the animal, have failed to furnish a comprehensive and definite concept of the metabolic and chemical changes taking place when benzoic acid is introduced into the organism. No attempt has ever been made to explain why man eliminates benzoic acid almost complete...

A convenient route to isoindolo[2,1-a]indol-6-ones has been developed starting from the appropriate 2-(N-phthaloyl)benzoic acids. Formation of the acid chlorides with thionyl chloride followed by heating with triethyl phosphite in a suitable solvent resulted in a multistep reaction giving tetracyclic β-ketophosphonates that on reduction with sodium borohydride gave the required indolones in goo...

I. S 24 perennial ryegrass was harvested at six stages of its growth from young leafy herbage to mature grass in which the seed had shed. 2. Two sheep were offered Ikg/d of each cut and two other sheep were offered 750 g/d of each cut of grass. 3. The contents of some possible precursors of the urinary aromatic acids excreted by sheep, namely, shikimic acid, quinic acid, chlorogenic acid, total...

We report the synthesis of six new heteroleptic Hg(II) complexes (1–6) with general composition [Hg(II) (bpy)L2] where bpy = 2,20-bipyridine, L = benzoic acid (1), 2-amino benzoic acid (2), 3-amino benzoic acid (3), 4-amino benzoic acid (4), 2-hydroxy benzoic acid (5), 4-hydroxy benzoic acid (6). 1, 2, 4–6 are monomer with hexa coordinated Hg(II) center whereas 3 is a zig–zag 1D-polymer with he...

Palladium catalysed carbonylation reactions using the meta- and para-iodo derivatives of all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane (4) are illustrated as the start point for a variety of functional group interconversions. The resultant benzaldehyde and benzoic acids offer novel building blocks for further derivatisation and facilitate the incorporation of the facially polarised all-cis-1,...

We present the linear response function of bond-orders (LRF-BO) based on a real space integration scheme for molecular systems. As in the case of the LRF of density, the LRF-BO is defined as the response of the bond order of the molecule for the virtual perturbation. Our calculations show that the LRF-BO enables us not only to detect inductive and resonating effects of conjugating systems, but ...