Our goal was to assess the microtubule translocating ability of individual ATPase subunits of outer arm dynein. Solubilized outer arm dynein from sea urchin sperm (Stronglocentrotus purpuratus) was dissociated into subunits by low ionic strength buffer and fractionated by zonal centrifugation. Fractions were assessed by an in vitro functional assay wherein microtubules move across a glass surfa...

Relation to high absorption fraction of Tc sestamibi by kidneys in heart scan and these organs are near to generation organs (Ovaries and uterus). Urinary system (kidneys and urinary bladder) are specified as sources organs. The main object of this study is to determine the absorbed dose in these critical organs. we have set amount of absorbed fraction radiopharmaceutical in position of kidneys...

  Determination of the total body absorbed dose consists of two parts: Beta radiation absorbed dose and gamma radiation absorbed dose. The first part is generally determined by clinical data, while the second part has a parameter called absorbed ratio and is determined by computational methods. The Monte-Carlo computational methods have been shown to be the most suita...

A microscopic mass balance approach has shown that the initial saturation (Is), absorption number (An), dose number (Do), and dissolution number (Dn) are four fundamental dimensionless parameters that can be used to estimate the fraction dose absorbed (~ of suspensions of poorly soluble drugs in humans. The dissolution number of a drug increases with decreasing its particle size. The effect of ...

Radiolabeled exendin is used for non-invasive quantification of beta cells in the islets of Langerhans in vivo. High accumulation of radiolabeled exendin in the islets raised concerns about possible radiation-induced damage to these islets in man. In this work, islet absorbed doses resulting from exendin-imaging were calculated by combining whole organ dosimetry with small scale dosimetry for t...

Radiation effects in pine forest Influence of IR on forest ecosystems most clearly revealed itself near the Chernobyl NPP (ChNPP), where magnitudes of absorbed doses reached 'lethal' values, as applied to conifers. Main contribution to absorbed dose was due to beta-radiation of short-living radionuclides. To largest extent the radiobiological effects appeared at injured plantations of pines and...

Changes in protein absorption through the intestinal mucosa occur with aging and might reflect modifications in enterocyte membrane characteristics. We have observed that bovine beta-lactoglobulin (beta-LG) was efficiently transported across the small intestine of adult rats in vitro and that 12-16% of the absorbed protein was recovered intact or as large hydrophobic peptides. Ten percent lacto...