Glaucoma is a multifactorial optic neuropathy in which the main therapeutic target is lowering of intraocular pressure (IOP) in order to retard the progression of existing structural and functional damage. The three mainstays of treatment are pharmacologic, laser, and surgical. The primary standard therapy in patients with open-angle glaucoma or ocular hypertension is topical medication. When m...

Eukaryotic DNA is organized into nucleosomes by coiling around core particles of histones, forming a nucleosomal filament. The significance for the conformation of the filament of the DNA entry/exit angle (alpha) at the nucleosome, the angle of rotation (beta) of nucleosomes around their interconnecting DNA (linker DNA) and the length of the linker DNA, has been studied by means of wire models ...

Let A be a densely defined closed, linear $$\omega$$ -sectorial operator of angle $$\theta \in [0,\frac{\pi }{2})$$ on Banach space X, for some $$\omega \mathbb {R}$$ . We give an explicit representation (in terms special functions) and study the precise asymptotic behavior as time goes to infinity solutions following diffusion equation with memory: $$\displaystyle u'(t)=Au(t)+(\kappa *Au)(t), ...

F(1)-ATPase is a rotary molecular motor in which the gamma-subunit rotates against the alpha(3)beta(3) cylinder. The unitary gamma-rotation is a 120 degrees step comprising 80 and 40 degrees substeps, each of these initiated by ATP binding and ADP release and by ATP hydrolysis and inorganic phosphate release, respectively. In our previous study on gamma-rotation at low temperatures, a highly te...

OBJECTIVE Fixed combination glaucoma medication is increasingly used in glaucoma treatment. There is a lack of comparative study in the literature of non-beta blocker combination agents used adjunctively with a glaucoma agent in a different class. The objective of this study is to evaluate the effect of intraocular pressure (IOP) control and tolerability of non-beta blocker combination suspensi...

Using a lossless dispersive apparatus consisting of six prisms, optimized to match a second-harmonic crystal phase-matching angle versus wavelength to second order, we efficiently doubled tunable fundamental light near 660 nm over a range of 80 nm, using a 4-mm-long type I beta -barium borate crystal without tuning the crystal angle. Another set of six prisms after the crystal realigned the pro...