The effects of chronically increasing (creatine-fed) or decreasing (beta-guanidinopropionic acid [beta-GPA]-fed) high-energy phosphates for up to 8 weeks on daily voluntary activity levels, swimming endurance capacity, electromyogram (EMG) activity, and the morphological and metabolic properties of single fibers in the soleus and extensor digitorum longus (EDL) muscles in young rats were determ...

The rates of activity of the dehydrogenase systems in Tetrahymena, which are concerned with carbohydrate oxidation, in descending order of activity are: lactic > isocitric > succinic = glucose > glucose-6-phosphate = 6-phosphogluconic = malic > glutamic = cytochrome linked alpha-glycerophosphate dehydrogenase. No evidence was obtained to indicate the presence of DPN linked alpha-glycerophosphat...

The monoglyceride pathway for the synthesis of triglycerides has been investigated employing subcellular fractions and whole cell preparations of white and brown adipose tissue. Conclusive evidence has been obtained for the monoglyceride pathway in these tissues by employing the 2-monoether analogue of 2-monoolein as the substrate. The monoglyceride and alpha-glycerophosphate pathways were prim...

Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol (TAG) and glycerophospholipids. Many enzymes belonging to the GPAT/AGPAT family have recently been identified and their physiological or pathophysiological roles have been proposed. The roles of GPAT/AGPAT in the synthesi...

BLANCHAER, M. C. Respiration of mitochondria of red and white skeletal muscle. Am. J. Physiol. 206(5) :1o15-1020. I g64.-Mitochondria of guinea pig red and white skeletal muscle were isolated in a medium containing 0.25 M sucrose, I mM ethylenediamine tetraacetate, and I y0 fraction V bovine albumin. Oxidative phosphorylation with pyruvate-malate as substrate was tightly coupled in both types o...