conclusions core-lds interaction may be an underlying molecular mechanism to induce liver steatosis in patients with hcv infection. this interaction is also crucial for efficient viral replication and persistence in infected cells. steatosis can also interfere with efficient standard interferon therapy treatment. management of steatosis should be considered along with standard care for achievin...

background: hepatitis c virus (hcv) is a main public health problem causing chronic liver infection and subsequently liver cirrhosis and lethal hepatocellular carcinoma (hcc). vaccination based on hcv capsid proteins has attracted a special interest for prevention of viral infections. the core protein is a basic and evolutionary most conserved protein, which regulates the cellular processes rel...

in the present study, the effect of core on shear lag phenomenon in tubular structures is investigated. three different tubular structure models including model without core, model with central core and model with central core but eliminated in last 15 stories have been analyzed. a shear lag index is defined for evaluating these models. from examination of the results, the effective influence o...

the objective of the present study was to identify managerial competencies. this study reviewed existing managerial competencies in a cultural context resulting in the development of a broad based psychometrically sound leadership questionnaire. the unit of analysis of the research was a theoretical and experimental research related to managerial competencies, provided from seventeen iranian an...

In this paper, we have investigated multi-item integrated production-inventory models of supplier and retailer with a constant rate of deterioration under stock dependent demand. Here we have considered supplier’s production cost as nonlinear function depending on production rate, retailers procurement cost exponentially depends on the credit period and suppliers transportation cost as a non-li...

abstract objectives: the purpose of this study was to investigate the relationship between core stability and lower extremity injuries in female athletes through functional tests. decreased core stability has been suggested to contribute to the etiology of lower extremity injuries. so far researches had been used non-functional tests to assess the core stability. material and methods: fifty col...

Background: Hepatitis C virus (HCV) is a main public health problem causing chronic liver infection and subsequently liver cirrhosis and lethal hepatocellular carcinoma (HCC). Vaccination based on HCV capsid proteins has attracted a special interest for prevention of viral infections. The core protein is a basic and evolutionary most conserved protein, which regulates the cellular processes rel...

in this study calf thymus chromatin was fractionated into active (s1 and s2) and inactive (p 2) chromatin. then the interaction of an anthracyc1ine antibiotic, adriamycin, with these fractions was investigated employing absorption and difference uv nis spectroscopy and sds and agarose gel electrophoreses. the results suggest that the binding of adriamycin to the s 1 fraction is slight but s2 an...

conclusions the canola oilseeds could provide a useful expression system to produce hcv core protein as a vaccine candidate. results western blot analysis using anti-his antibody confirmed the presence of a 15 kda protein in the seeds of t1 transgenic lines. the amount of antigenic protein accumulated in the seeds of these transgenic lines was up to 0.05% of the total soluble protein (tsp). mat...