The number of imaging data sets has significantly increased during radiation treatment after introducing a diverse range of advanced techniques into the field of radiation oncology. As a consequence, there have been many studies proposing meaningful applications of imaging data set use. These applications commonly require a method to align the data sets at a reference. Deformable image registra...

In 8] a new model validation method was proposed that is based on the estimation of an unbiased model of the model error which relates the inputs to the simulation errors. In this paper, we extend this methodology to closed-loop validation , i.e. the validation of an open-loop model on the basis of closed-loop validation data. We show that, perhaps surprisingly, the same model may fail to be va...

In this text, an unconventional paradigm for robotic multisensory perception and action will be presented in the form of a generalisation of a framework devised in previous work by the authors, the Bayesian Volumetric Map (BVM). The BVM, a log-spherical inference grid providing an egocentric and probabilistic representation of spatial information, was designed to bridge multisensory perception ...

Paclitaxel belongs to the taxanes family and it is used, alone or in multidrug regimens, for the therapy of several solid tumours, such as breast-, lung-, head and neck-, and ovarian cancer. Standard dosing of chemotherapy does not take into account the many inter-patient differences that make drug exposure highly variable, thus leading to the insurgence of severe toxicity. This is particularly...

The development of biosimilar products is expected to grow rapidly over the next five years as a large number of approved biologics reach patent expiry. The pathway to regulatory approval requires that similarity of the biosimilar to the reference product be demonstrated through physiochemical and structural characterization, as well as within in vivo studies that compare the safety and efficac...

The reliability of analytical findings is a matter of great importance in forensic and clinical toxicology, as it is of course a prerequisite for correct interpretation of toxicological findings. Unreliable results might not only be contested in court, but could also lead to unjustified legal consequences for the defendant or to wrong treatment of the patient. The importance of validation, at l...

This study focuses on evaluating the suitability of three interpolation methods in terms of their accuracy, for small urban catchments. The Bridgewater Creek catchment in south Brisbane is the region of study. Thirteen storm events measured over 24-hours are interpolated using an inverse-distance weighted average method, thin plate smoothing spline, and an ordinary kriging technique. The delete...