Drug interactions with digoxin are important because of this agent's narrow therapeutic index. Among the drugs that can decrease digoxin bioavailability are cholestyramine, antacid gels, kaolin-pectate, certain antimicrobial drugs and cancer chemotherapeutic agents. In selected patients, antibiotics may enhance digoxin bioavailability by eliminating intestinal flora that metabolize digoxin. Ant...

ruminal bacteria and protozoa provide excellent organic phosphorus (p) sources for the host animal. this experiment was conducted to compare the bioavailability of bacterial and protozoal p in comparison with that of dicalcium phosphate (dcp) as a reference phosphorus source. bacteria and protozoa were isolated from the rumen contents of dairy cows and the chick-model was used to determine the ...

This study aims to explore the effects of the distribution, transformation and bioavailability of different fractions of copper (Cu) and selenium (Se) in co-contaminated soils on soil enzymes, providing references for the phytoremediation of contaminated areas and agriculture environmental protection. Pot experiments and laboratory analysis were used to investigate the transformation and bioava...

this research project was conducted to evaluate bioavailability and chemical properties of different zinc sources in broiler chickens when fed by practical diets. for that, 312 day-old male ross 308 broiler chicks were fed from 8-28 day to estimate the biological availability of four zinc sources. chicks were allocated randomly to 13 experimental diets in a 3 × 4 factorial design. diets include...

atorvastatin calcium, the lipid lowering agent, is taken as a model drug characterized by poor water solubility and bioavailability. in this study an attempt was made for preparation of nanocrystals using high pressure homogenization. a number of stabilizers were included as well as polymers at different concentrations, and the formulations were homogenized for ten cycles at a pressure of 1000 ...

Background and Objectives: In the original in vitro method for evaluation of iron bioavailability using caco-2 cell model, ferritin formation by cells is considered as a functional indicator of both absorption and utilization of iron. However, as iron is measured in the tested material and then ferritin concentration is measured in caco-2 cell lysate, it is almost impossible to have a concrete ...

PURPOSE Agomelatine is a novel antidepressant drug suffering from an extensive first-pass metabolism leading to a diminished absolute bioavailability. The aim of the study is: first to enhance its absolute bioavailability, and second to increase its brain delivery. METHODS To achieve these aims, the nasal route was adopted to exploit first its avoidance of the hepatic first-pass metabolism to...

Poorly water soluble molecules are typically formulated for improving their dissolution rate and storage stability by increasing active drug surface area that come in the contact with the dissolution medium [4]. Most important characteristics of nanosuspensions are their exhibited particle size; polydispersity index, drug saturation solubility, physical stability, dissolution rate and bioavaila...