The development of several highly effective biologic drugs in the past decade has revolutionized the treatment of moderate-to-severe plaque psoriasis. With increased understanding of the immunopathogenesis of psoriasis, the emphasis has turned toward more specific targets for psoriasis drugs. Although the complex immunological pathway of psoriasis is not yet completely understood, current model...

BACKGROUND The prognosis of children with juvenile dermatomyositis (JDM) has improved remarkably since the 1960's with the use of corticosteroid and immunosuppressive therapy. Yet there remain a minority of children who have refractory disease. Since 2003 the sporadic use of biologics (genetically-engineered proteins that usually are derived from human genes) for inflammatory myositis has been ...

summary: adult-onset still’s disease (aosd) is a rare systemic inflammatory disorder of unknown etiology. it is characterized by high grade fever, skin rash, arthritis, leukocytosis, increased esr, crp and liver enzyme levels and high levels of ferritin. the treatment of aosd includes nsaids, steroids, and disease-modifying antirheumatic drugs (dmards). recently biologic agents have been used f...

Tumour necrosis factor-alpha inhibitors (TNF-blockers) are recommended for the treatment of predominantly axial spondyloarthritis (SpA), after failure of non-steroidal anti-inflammatory drugs (NSAIDs). TNF-blockers are very effective drugs and also show a sustained and stable long-term response in axial SpA. A few trials indicated that withdrawal of TNF-blockers in longstanding ankylosing spond...

OBJECTIVE To analyze the resource utilization in rheumatoid arthritis (RA) patients and predictive factors in and patients treated with biological drugs and biologic-naïve. METHODS A cross-sectional study was performed in a sample including all regions and hospitals throughout the country. Sociodemographic data, disease activity parameters and treatment data were obtained. Resource utilizatio...