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Chrysotherapy has now become a recognized form of treatment in rheumatoid arthritis and much experimental work has been done to determine the fate of gold salts in the body. Kling and his colleagues (1939) showed that gold compounds were deposited mainly in reticulo-endothelial cells, of which synovial membrane contains a large number. They were able to detect spectrographically the presence of...

Mass-spectrometric interface for the measurement of anaesthetic agent concentration in biological fluids (blood plasma and cerebrospinal fluid) is described. Sampling of biological fluids was performed during balanced inhalational (desflurane, fentanyl) anaesthesia and total intravenous (propofol, fentanyl) anaesthesia. The described method for drug concentration measurement in biologic fluids ...

Detection and identification of human body fluids represent very important aspects of forensic biology, since in the case of numerous offences, a firm determination of the DNA source (e.g. semen, saliva, epithelium) rather than establishing the DNA profile alone is of great significance. The presently employed routine methods are insufficient: there are no specific tests confirming the presence...

A possibility to use the Membrane-Introduction Mass Spectrometry (MIMS) with membrane separator interface has evolved into a powerful method for measurement of anaesthetic agents absolute concentration in blood plasma and cerebrospinal fluid for the study of blood-brain barrier (BBB) properties. Recent advanced a new membrane material was used for drug concentration measurement in biologic flui...

Enhanced detection of hematogenous circulating prostatic cells in patients with prostate adenocarcinoma using prostate-specific membrane antigen (PSM)-based nested reverse transcription-polymerase chain reaction assay. Clin Chem 1995;41:1698–704. 10. Matsumura M, Niwa Y, Kato N, Komatsu Y, Shiina S, Kawabe T. Detection of alpha-protein mRNA, an indicator of hematogenous spreading hepatocellular...