Diketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product.

To overcome the usually low productivities of the C=C bond bioreduction of α,β-unsaturated aldehydes we combined the in situ substrate feeding product removal (SFPR) technology with a cascade system comprising an isolated ene-reductase and a chemoselective alcohol dehydrogenase.

The effect of surfactants on the bioreduction of acetophenones mediated by carrot (Daucus carota) root was investigated. Among the tested surfactants, Tween® 20 slightly improved the conversion. The amount of surfactant was optimised, and the presented methodology was applied to other substituted acetophenones, which led to the preparation of their respective optically enriched 1-phenylethanols...

Iron-bearing phyllosilicate minerals help establish the hydrogeological and geochemical conditions of redox transition zones because of their small size, limited hydraulic conductivity, and redox buffering capacity. The bioreduction of soluble U(VI) to sparingly soluble U(IV) can promote the reduction of clay-Fe(III) through valence cycling. The reductive precipitation of U(VI) to uraninite was...

PURPOSE Tumor hypoxia is associated with poor prognosis and a more malignant tumor phenotype. SR-4554, a fluorinated 2-nitroimidazole, is selectively bioreduced and bound in hypoxic cells. We present validation studies of SR-4554 as a noninvasive hypoxia marker detected by fluorine-19 magnetic resonance spectroscopy ((19)F MRS) in the P22 carcinosarcoma, a tumor with clinically relevant hypoxia...

the potential of citrobacter freundii, a gram negative bacteria for the remediation of hexavalentchromium (cr(vi)) and trivalent chromium (cr(iii)) from aqueous solutions was investigated. bioremediationof cr(vi) involved both biosorption and bioreduction processes, as compared to only biosorption processobserved with respect to cr(iii) bioremediation. in the case of cr(vi) bioremediation studi...