Introduction: According to the cumulative evidence, genes encoding GABA receptors inhibit neurotransmitters in CNS and are intricately involved in the pathogenesis of mood disorders. Based on this hypothesis, these genes may be expressed in bipolar patients. As a result, we evaluated the gene expressions of GABA-β3 and HT1D receptors to assess their associations with bipolar mood disorder....

conclusions these findings support that the careful evaluation and prospective following of the psychopathology of children of parents with bipolar disorder are critical for early identification and treatment. results there were statistically significant differences between children of parents with and those without bipolar disorder regarding attention deficit hyperactivity disorder, opposition...

A significant overlap between childhood mood disorders and many aspects of attention deficit hyperactivity disorder (ADHD) has been established. High rates of co-occurrence, familial aggregation, and more severe clinical manifestations of the illnesses when they are comorbid suggest that common genetic and environmental factors may contribute to the development of both disorders. Research on th...

BACKGROUND We investigated our translation of The Mood Disorder Questionnaire (MDQ) as a screening instrument for bipolar disorder in a psychiatric setting in Finland. METHODS In a pilot study for the Jorvi Bipolar Study (JoBS), 109 consecutive non-schizophrenic psychiatric out- and inpatients in Espoo, Finland, were screened for bipolar disorder using the Finnish translation of the MDQ, and ...

Bipolar disorder, formerly known as manic-depressive disorder, consists of often recurrent and severe mood episodes. Roughly 1% of children are diagnosed with bipolar disorder; the prevalence doubles in adulthood. The intense mood swings and periods of depression contribute to the significant morbidity and mortality associated with this disorder, which ranks seventh among worldwide causes of no...

In general, bipolar disorder with its classical presentation of regularly recurring manic and depressive episodes can be well diagnosed in adults and adolescents. However, bipolar disorder in children is a controversial issue, difficult to diagnose and to distinguish from other illnesses that frequently occur in childhood. In the US, where the diagnosis of'bipolar disorder' is made relatively o...

Major depressive disorder and bipolar disorder share symptoms that may reflect core mood disorder features. This has led to the pursuit of intermediate phenotypes and a dimensional approach to understand neurobiological disruptions in mood disorders. Executive dysfunction, including cognitive control, may represent a promising intermediate phenotype across major depressive disorder and bipolar ...

BACKGROUND Numerous studies have observed that offspring of bipolar parents manifest a broad spectrum of psychiatric disorders. We tested the hypothesis that in high risk offspring, bipolar disorder evolves in a predictable clinical sequence from non-specific (non-mood) to specific (mood) psychopathology. METHODS Offspring from well-characterized families with one bipolar parent (high risk) o...

objective: given that the topic of bipolar disorder overdiagnosis has been relatively neglected in the literature and considering its significance in psychiatric training. the present study was conducted through an objective structured clinical examination (osce) on psychiatric residents to assess the validity of their clinical diagnosis. methods: twenty forth residents participated in the exam...