Several new 2-pyridyl-4-thiazolidinones are synthesized in an efficient manner evading using any catalyst or base. Simple workup procedure, good yields, and mild reaction conditions are the salient features of this method. All the synthesized compounds are screened for antimicrobial activity against several organisms.

In the present research work new 4-thiazolidinones possessing dual cyclooxygenase/lipoxygenase inhibition were synthesized. Sixteen N-[2-(aryl/substitutedaryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide derivatives(5a-q) differing by the phenyl group substitution were synthesized by sonication. Compounds N-[2-(4-chlorophenyl)-4-oxo-1, 3thiazolidin-3-yl] pyridine-4-carboxamide (5d) and N-...

the development of multicomponent reactions (mcrs) designed to produce elaborate biologically active compounds has become an important area of research in organic, combinatorial, and medicinal chemistry. a comparative study of the synthesis of new bis-spiro-oxindolo(pyrrolizidines/pyrrolidines) ring systems by the cycloaddition of azomethine ylides generated by a decarboxylative route from sarc...