BACKGROUND Early-life exposure to bisphenol A (BPA) may increase childhood obesity risk, but few prospective epidemiological studies have investigated this relationship. OBJECTIVE We sought to determine whether early-life exposure to BPA was associated with increased body mass index (BMI) at 2-5 years of age in 297 mother-child pairs from Cincinnati, Ohio (HOME Study). METHODS Urinary BPA c...

A hydrophobic restorative composite based on a fluorocarbon analog of an alkyl methacrylate and a bisphenol adduct was formulated into a onepaste system, which polymerized in the presence of blue light. Physical, mechanical, and waterrelated properties were determined. High contact angles and low water sorption were shown by the experimental composite. Capillary penetration of oral fluids aroun...

A highly sensitive method for the determination of bisphenol-A in water with semi-micro column high-performance liquid chromatography using 2-methoxy-4-(2-phthalimidinyl)phenylsulfonyl chloride as a fluorescent labeling reagent has been developed. The labeling reaction was carried out at 70 degrees C for 20 min in borate buffer (pH 9.5). The derivative eluted at 11.6 min on a reversed-phase col...

Bisphenol A (BPA) has received considerable attention as an endocrine disrupting chemical and a possible substrate for genotoxic metabolites. BPA metabolism leads to formation of electrophilic o-quinones cable of binding to DNA and other endogenous nucleophiles. We have structurally identified the products resulting from the reaction of bisphenol A-3,4-quinone (BPAQ) with N-acetylcysteine (NAC)...

Bisphenol A (BPA) has been shown to cause adverse health effects in animals, but attempts to extrapolate human health effects from this evidence are impeded by unanswered questions about routes and levels of exposure, metabolism, and whether animal models are appropriate proxies for humans. New findings show the kinetics of BPA metabolism are very similar in humans, monkeys, and mice and also s...

The suspected endocrine disruptor bisphenol A (BPA) is associated with the manufacture, distribution, and use of epoxy resins and polycarbonate plastics; thus, studies of this compound have focused primarily on urban areas in developed countries. This small study investigating urinary BPA of 109 people was conducted in the urban United States, urban Jamaica, and rural Ghana. Additionally, local...

Bisphenol A (BPA) is being removed from many consumer products because of concerns about the chemical’s potential to disrupt the endocrine system. A chemical analog known as bisphenol S (BPS) has been adopted as an alternative in products such as water and baby bottles, thermal paper, and linings of metal cans. In this issue of EHP, a new study shows that BPS has nearly identical impacts on the...

This study compared the degradation of indigenous bisphenol A (BPA) and triclosan (TCS) in a biosolids-amended soil, to the degradation of spiked labelled surrogates of the same compounds (BPA-d16 and TCS-(13)C12). The aim was to determine if spiking experiments accurately predict the degradation of compounds in biosolids-amended soils using two different types of biosolids, a centrifuge dried ...

migration of compounds from packaging materials is one of the most important aspects of food safety. epoxy resins have been in inner coatings of food cans since the 1960s. these resins can be produced from bisphenol-a diglycidyl ether (badge) that is also utilized as a starter. migration of potentially toxic compounds in epoxy resins used for commercial cans is a very important food safety issu...

results the main pathological finding observed in the prostrate and seminal vesicle glands, using light microscope, revealed congestion in the connective tissue and vacuolization in the secretory units of epithelial cells and epithelium rupture at 50 and 100 µg/kg doses of bpa. ultrastructure study showed vacuolization of mitochondria, condensation of nuclei and disappearance of nucleus in the ...