Interstitial cystitis or painful bladder syndrome is a chronic, often debilitating, condition largely defined by symptoms of urinary urgency and frequency associ‐ ated with pelvic pain that varies with bladder filling.1 Unlike bladder inflammation caused by bacterial infec‐ tion, the condition occurs in the absence of urinary tract infection or other obvious pathology. Resulting discomfort may ...

Hyperexcitability of C-fiber bladder afferent pathways has been proposed to contribute to urinary frequency and bladder pain in chronic bladder inflammation including interstitial cystitis. However, the detailed mechanisms inducing afferent hyperexcitability after bladder inflammation are not fully understood. Thus, we investigated changes in the properties of bladder afferent neurons in rats w...

Novel longer lasting inflammatory bladder animal models are needed to better understand the pathophysiology of chronic cystitis. We previously developed a relatively long-lasting mouse cystitis model by intravesical injection of hydrogen peroxide (H2O2). To further evaluate its pathophysiology, in this study, we established and analyzed a rat cystitis model. Under anesthesia, 1.5% H2O2 solution...

Chronic inflammatory bladder disorders, such as interstitial cystitis/bladder pain syndrome, are associated with poor quality of life. The exact pathological processes remain unclear, but accumulating evidence suggests that reactive oxidative species (ROS) are involved in urinary bladder disorders. Transient receptor potential ankyrin 1 (TRPA1), the most sensitive TRP channel to ROS, was shown ...

Interstitial cystitis causes disabling bladder pain and is usually diagnosed in the absence of infection. We describe a patient with interstitial cystitis who had high urinary levels of polyomavirus that decreased dramatically after initiation of intravesical cidofovir treatment; the patient also showed substantial improvement in symptoms. Another patient had milder symptoms of cystitis and int...

Cystitis is an inflammation of the urinary bladder which common in domestic animals as part a tract infection. Clinical symptoms cystitis are lower abdominal pain on palpation, dysuria (animals show signs every attempt to urinate) and hematuria. The diagnosis can be obtained through anamnesis, physical examination, clinical symptoms, urinalysis with sediment blood chemistry examinations such ur...

Interstitial cystitis/bladder pain syndrome (IC/BPS) and vulvodynia are chronic pain syndromes that appear to be intertwined from the perspectives of embryology, pathology and epidemiology. These associations may account for similar responses to various therapies.

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