Background Isolation of brain-secreted extracellular vesicles (BEVs) from blood, provides a novel, minimally invasive way to sample brain tissue in individuals along the Alzheimer’s disease (AD) continuum. BEVs blood demonstrate enormous potential serve as novel AD biomarker discovery platform and treatment tool. However, at present, BEV isolation validation protocols vary center center. Given ...

background/objective: development of a new enzyme-linked immunosorbent assay (elisa) for screening human blood serum and plasma for antibodies to human immunodeficiency virus type 1 (hiv1) and type 2 (hiv2) as hiv1/2rec elisa diagnostic kit based on e. coli derived soluble recombinant proteins.   methods : polypeptides corresponding to hiv1 gp41 and hiv2 gp36 immunodominant regions and hiv1 gag...

Hepatitis C virus (HCV) is responsible for a vast majority of liver failure cases. HCV is a kind of blood disease appraised to chronically infect 3% of the worlds’ population causing significant morbidity and mortality. Therefore, a complete knowledge of humoral responses against HCV, resulting antibodies, and virus-receptor and virus-antibody interactions, are essential to design a vaccine. HC...

The aim of our study was to evaluate the trypsin-like serine proteases (TLPs) distribution between systemic circulation and pancreatic tissue investigate peculiarities their involvement in extracellular matrix components degradation patients with pathologies electrophoretic analysis methods using. Тhe Khmelnitsky Regional Clinical Hospital aged 28-89 were selected for this study: 20 people chro...

Background: Rotavirus infection is one of the most common gastroenteritis in the world, and a million cases are registered to enter hospital every year. Promyelocytic leukemia proteins (PMLs) are IFN-up-regulated proteins, and one of their critical functions is working as antiviral proteins. Recently, promyelocytic leukemia isoform II (PML-II) has been depicted as an isoform responsible for the...