Bloom filters and Counting Bloom Filters (CBFs) are widely used in networking device algorithms. They implement fast set representations to support membership queries with limited error. Unlike Bloom filters, CBFs also support element deletions. In the first part of the talk, I will introduce a new general method based on variable increments to improve the efficiency of CBFs and their variants....

The proper distribution of crossovers during meiosis I ensures accurate chromosome segregation at the first meiotic division. A new study reveals both the consequences of improper crossover patterning in Drosophila and the role of Blm helicase in controlling this patterning.

RecQ helicases play an important role in preserving genomic integrity, and their cellular roles in DNA repair, recombination, and replication have been of considerable interest. Of the five human RecQ helicases identified, three are associated with genetic disorders characterized by an elevated incidence of cancer or premature aging: Werner syndrome, Bloom syndrome, and Rothmund-Thomson syndrom...

Bloom filters and Counting Bloom Filters (CBFs) are widely used in networking device algorithms. They implement fast set representations to support membership queries with limited error. Unlike Bloom filters, CBFs also support element deletions. In the first part of the talk, I will introduce a new general method based on variable increments to improve the efficiency of CBFs and their variants....

The RECQL4 helicase gene is a member of the RECQL gene family, mutated in some Rothmund-Thomson syndrome (RTS) patients. Other members of this gene family are BLM mutated in Bloom syndrome, WRN mutated in Werner syndrome and RECQL and RECQL5. All polypeptides encoded by RECQL genes share a central region of seven helicase domains. The function of RECQL4 remains unknown, but based on the domain ...

The RecQ family DNA helicases Werner syndrome protein (WRN) and Bloom syndrome protein (BLM) play a key role in protecting the genome against deleterious changes. In humans, mutations in these proteins lead to rare genetic diseases associated with cancer predisposition and accelerated aging. WRN and BLM are distinguished from other helicases by possessing signature tandem domains toward the C t...

Several eukaryotic homologs of the Escherichia coli RecQ DNA helicase have been found. These include the human BLM gene, whose mutation results in Bloom syndrome, and the human WRN gene, whose mutation leads to Werner syndrome resembling premature aging. We cloned a Drosophila melanogaster homolog of the RECQ helicase family, Dmblm (Drosophila melanogaster Bloom), which encodes a putative 1487-...

Bloom Syndrome (BS) is a genetic DNA repair disorder, caused by mutations in the BLM gene. The clinical phenotype includes growth retardation, immunodeficiency and strong predisposition to different types of malignancies. Treatment malignancies BS patients with radiotherapy or chemotherapy believed be associated increased toxicity, but laboratory data are lacking. We collected two Dutch solid t...