Risk of colorectal cancer (CRC) after exposure to low linear energy transfer (low-LET) radiation such as γ-ray is highlighted by the studies in atom bomb survivors. On the contrary, CRC risk prediction after exposure to high-LET cosmic heavy ion radiation exposure is hindered due to scarcity of in vivo data. Therefore, intestinal tumor frequency, size, cluster, and grade were studied in APC(Min...

INTRODUCTION Malignant melanomas account for 5% of all skin cancers and usually have a fatal clinical course. Additionally, the incidence of melanoma increases more rapidly than in any other cancer, and this has been attributed to the development of highly sensitive diagnostic techniques, mainly dermoscopy, which allows for early diagnosis. The phenotypic manifestations of gene/environment inte...

OBJECTIVE To use toluidine blue intra-operatively to identify tumour involved margins after the removal of oral cavity squamous cell carcinoma, and to compare the findings with those of final histopathology. METHODS The study was conducted at the Aga Khan University Hospital from December 1, 2009, to March 14, 2010, and comprised 56 consecutive patients with biopsy-proven squamous cell carcin...

144 Metabolomics studies of chronic atrophic gastritis cold and heat syndrome M.L. Wang, C.L. Zheng, Y.W. Zhou, T.G. Liu, Y.B. Li, H. Xie, Y. Chang, W.C. Liu, G.G. Chen, X.L. Sun, Y.H. Zhao, Z.H. Li 1 Beijing Jiangong Hospital, Beijing 100054,China 2 Beijing Gulou Hospital of Traditional Chinese Medicine, Beijing 100009, China 3 Beijing University of Chinese Medicine, Beijing 100029,China 4 Bei...

The two-phase issue in the O(n) non-linear σ-model: a Monte-Carlo study Our paper [1] has motivated a comment [2] by A. Patrascioiu and E. Seiler which we reply in this note. The remarks in [2] concern three statements that the authors select from our paper: i) " The results for O(8) support the asymptotic freedom scenario ". The authors in [2] argue that at small˜β ≡ β/8 the O(8) is expected t...

This study was done to evaluate the effect of sperm source on chromatin integrity and ICSI outcomes. One hundred and thirteen samples containing epididymal aspirates of 57 obstructive azoospermic men and 56-ejaculated semen of normozoospermic men were included in this study. Sperm chromatin status was evaluated by Chromomycin A3 (CMA3), Aniline Blue (AB) and Toluidine Blue (TB). Fertilization r...

The cyclobutane pyrimidine dimer (CPD) is a major type of DNA damage induced by ultraviolet B (UVB) radiation. CPD photolyase, which absorbs blue/UVA light as an energy source to monomerize dimers, is a crucial factor for determining the sensitivity of rice (Oryza sativa) to UVB radiation. Here, we purified native class II CPD photolyase from rice leaves. As the final purification step, CPD pho...

UNLABELLED BACKGROUND The reported rates of Barrett's esophagus (BE) ranged from 2.6% to 23% in Indian patients with gastro-esophageal reflux disease (GERD) symptoms. The role of methylene blue chromoendoscopy during endoscopy, either for the diagnosis of Barrett's esophagus or for the detection of dysplasia and early cancer, remains controversial. AIM Our study was designed to find out the e...