BACKGROUND Alongside the extent of removal and patients' survival in the management of brain tumors, health-related quality of life (HRQOL) has become an important consideration. The purpose of this study is to evaluate the change of HRQOL in brain tumor patients before and after surgery and to assess the associated factors that contribute to the change of HRQOL. METHODS A total of 258 patien...

Abstract BACKGROUND Clinical outcome assessments (COAs) are a key component of patient-centered assessment net clinical benefit in trials. In neuro-oncology, unique symptoms, treatment-related toxicities, and overall poor prognosis further necessitate focus on symptom management quality life. We conducted computational survey trends COA use past ongoing neuro-oncology METHODS Neuro-oncology tri...

BACKGROUND The European Organization for Research and Treatment of Cancer Quality of Life Brain Cancer Module has been translated into Korean, but to date, its reliability and validity have been evaluated in a pilot study alone. The European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire is, overall, a valid instrument to assess the health-related quality o...

The role of reoperation for recurrent glioblastoma (GBM) remains unclear. Prospective studies are lacking. Here, we studied the association of clinical outcome with extent of resection upon surgery for recurrent GBM in the patient cohort of DIRECTOR, a prospective randomized multicenter trial comparing 2 dose-intensified temozolomide regimens at recurrence of GBM. We analyzed prospectively coll...

Abstract Background Meningiomas are the most common CNS tumors and majority is regarded as benign. However, a subset of patients presents with complex involving several anatomic compartments skull base - eluding any concepts gross total resection. Proton therapy (PT) applied definitive treatment for primary or recurrent disease postoperatively following subtotal We report on first 100 adult tre...