Since 1998, we are performing clinical studies on treatment of GBM using conventional fractionated photon radiation therapy (CRT), proton beam therapy (PBT) or boron neutron capture therapy (BNCT). We investigated whether these radiation modalities improves the survival of patients with GBM. Sixty-eight cases of newly diagnosed GBM have been treated in our institution. After surgery, radiation ...

The aim of the present study was to evaluate the effect of bevacizumab on local tumor response and lung metastatic potential during boron neutron capture therapy (BNCT) and in particular, the response of intratumor quiescent (Q) cells. B16-BL6 melanoma tumor-bearing C57BL/6 mice were continuously administered bromodeoxyuridine (BrdU) to label all proliferating (P) tumor cells. The tumors were i...

background: boron neutron capture therapy (bnct) is a radiotherapy that combines biological targeting and high linear energy transfer. a potential therapeutic approach for non-small cell lung cancer (nsclc) is considered. however, dose in lung tumor is not homogeneous, and it will reduce the effect of bnct treatment. in order to improve the dose distribution of bnct, the multi-field irradiation...

Abstract Background We previously reported a phase II trial of accelerator-based boron neutron capture therapy (BNCT) for patients with malignant glioma, which showed long median overall survival 18.9 months. However, progression-free was 0.9 In this trial, bevacizumab permitted to use after progressive disease. The reason discrepance between short and speculated that progression disease includ...

Abstract Boron neutron capture therapy (BNCT) is a promising cancer treatment that selectively destroys tumor cells using beam. However, accurately and fast measuring the spatial distribution of flux critical to ensuring effective treatment. To address this challenge, Micromegas detectors are applied for first time measure beam in BNCT. Due high flux, large area, multiple components BNCT beam, ...

Background: Boron neutron capture therapy (BNCT) is a binary modality based on the nuclear reaction 10B (n, α) lithium-7 (7Li) that has been used to treat variety of tumors, among these, cutaneous melanoma (CM). In previous boron biodistribution studies in agreement with personalized oncology, we have demonstrated boronophenylalanine (BPA) uptake can be correlated tumoral temperature and viabil...

Carborane-appended 5-thio-Dglucopyranose (TDG) and deoxyribose derivatives were synthesized and evaluated for accumulation in cancer cells, cytotoxicity, and efficacy in an in vitro boron neutron capture therapy (BNCT) assay. The nidocarborane-appended sugar conjugates were found to be less cytotoxic than their closo-carborane analogues. Biological evaluation with human hepatocellular carcinoma...

Radiation sensitive polymer gels are among the most promising three-dimensional dose verification tools developed to date. Polymer gel dosimeter known by the acronym MAGIC has been tested for evaluation of its use in boron neutron capture (BNCT) dosimetry. We irradiated a large (diameter 10 cm, length 20 cm) cylindrical gel phantom in the epithermal neutron beam of the Finnish BNCT facility at ...

BACKGROUND Osteosarcoma is the most frequent primary malignant bone tumour, and its incidence is higher in children and adolescents, for whom it represents more than 10% of solid cancers. Despite the introduction of adjuvant and neo-adjuvant chemotherapy that markedly increased the success rate in the treatment, aggressive surgery is still needed and a considerable percentage of patients do not...