Medicinal plants have curative properties due to the presence of various complex chemical compositions, which are found as secondary plant metabolites in one or more parts of the plant. The aim of this study was to compute the antidiabetic activity of Holarrhena antidysenterica   seeds extract in streptozotocin-induced diabetic rats. The experimental protocol designed as animals were divided i...

OBJECTIVES Voriconazole is a second-generation triazole antifungal, approved by the FDA in 2002. Despite a decade of experience with voriconazole, there are limited published data analysing serum concentrations and toxicity in obese patients. Therefore, we evaluated voriconazole trough serum concentrations in obese and normal-weight patients in a retrospective cohort study. METHODS Voriconazo...

Objective: The aim of the study is to analyze the antidiabetic effect of oral administration of acetone extract of Carissa spinarum (C. spinarum) leaves on blood glucose, haemoglobin, plasma insulin and lipid peroxidation to alloxan-induced diabetic rats. Method: Diabetes mellitus was induced by injection of alloxan (150mg/kg body weight), via the intraparitoneally. The extract was administered...

BACKGROUND The positive impact of Roux-en-Y gastric bypass on weight, comorbidities, and health-related quality of life is well documented. However, 50 percent of patients regain some of the lost weight after 2 years with Roux-en-Y gastric bypass and present a mean weight regain of 10 to 15 percent after several years, partially losing the previously obtained benefits. The authors hypothesize t...

We sought to determine if decrements in the mass of fat-free body mass (FFM) and other lean tissue compartments, and related changes in protein metabolism, are appropriate for weight loss in obese older women. Subjects were 14 healthy weight-stable obese (BMI > or =30 kg/m(2)) postmenopausal women >55 yr who participated in a 16-wk, 1, 200 kcal/day nutritionally complete diet. Measures at basel...

AIMS The association between recent and more distant weight changes before and after the diagnosis of type 2 diabetes has been little researched. The aim of this study is to determine the influence of patients' weight history before diabetes diagnosis on the observed 6-year weight changes after diagnosis. METHODS A clinical cohort study combined with self-reported past weight history. In tota...

Pharmacokinetic parameters of 2-(allylthio)pyrazine (2-AP) were evaluated after i.v. administration of the drug (10, 20, 50, and 100 mg/kg body weight) and oral administration of the drug (10, 50, and 100 mg/kg body weight) to rats. The hepatic, gastric, and intestinal first-pass effects of 2-AP were also measured after i.v., intraportal, intraduodenal, and oral administration of the drug (10 a...

College students, especially females, gain weight their freshman year. Yet, what happens after this first year? This study’s purposes were to compare changes and rates of change in weight, body mass index (BMI), body composition (percent body fat, fat mass, fat free mass) and waist circumference between the freshman academic year and the following summer among female college students. Summer we...

monary hyperventilation using a closed circuit apparatus designed for this purpose. A highly significant relation was found between oxygen uptake and patient surface area given by the regression equation V2=i6-5 (body weight in kg)213-3.8 ml/min (mean V02= I65 mll minIm2), and between VO2 and body weight given by V°2= 6-74e0076kg+ 4* Values for T02 kg variedfrom Io ml/min per kg to 5 ml/min per...

Clinical trials of Ivermectin in single oral doses of 200, 400, and 1,000 mg/kg body weight or in multiple doses of 200 mg/kg body weight for 5 consecutive days were performed in leaf monkeys (Presbytis cristatus) infected with Wuchereria kalimantani. Optimal microfilaricidal effect occurred at 200 mg/kg body weight. The drug was less effective than diethylcarbamazine in this animal model for h...