Objective: To test the hypothesis that zoledronic acid will inhibit tumor-induced osteolysis and reduce tumor growth and invasion in a xenograft mouse model of bone invasive oral squamous cell carcinoma (OSCC). In humans, OSCC is the 6th most common cancer in the world. Bone invasion frequently occurs and is associated with poor prognosis and reduced survival. OSCC is the most commonly diagnose...

A recent article in PNAS by Sahle et al. (1) entitled “Hominid butchers and biting crocodiles in the African Plio–Pleistocene” is an important contribution to our theoretical and methodological approaches to human origins research. It emphasizes the problem of equifinality in prehistoric studies (different agencies producing the same or similar results or end products), cutmarks from stone tool...

This study examines the osteological changes in the hands and fingers of rock climbers that result from intense, long-term mechanical stress placed on these bones. Specifically, it examines whether rock climbing leads to metacarpal and phalange modelling in the form of increased cortical thickness as well as joint changes associated with osteoarthritis. This study also attempts to identify spec...

Technical advances in 3D morphometrics and other forms of digital analysis allow for detailed measurements dental metrics yet, consistently, anthropologists show a publishing preference using calipers. It is possible that this reflects the often complex field settings, wide global distribution sample collections, or simple fact calipers are relatively low maintenance cost technology. Similarly,...

Objective- To describe the normal sonographic images of the soft tissues of the dorsal and palmar aspects of the fetlock region in the draught horses.   Design- Descriptive study.   Animals- Five clinically and radiographically normal draught male horses were used during this study.   Procedures- Horses were examined both radiographic and ultrasound ante mortem and post mortem. Based on the pro...

To determine If patients with rest angina have more severe regional Isehemla than padents with exertlonal aiigln., we compared the severity of left coronary artery (LCA) stenods In 29 patIents with transient anterior chemIc S’ -T changes at rest, and 30 patIents with anterior ST changes only during exertion. The percentage diameter stenosis w measured with Vernier calIpers (2 X lesion diameter ...