Background: Effects of estrogen on bone metabolism and its protective role on prevention of osteoporosis are well   documented. However, the efficacy of estrogen treatment on bone healing is not well investigated. The drug can be delivered both systemically or locally to the bone with differences in concentrations and side effects. The aim of this study was to investigate the effect of lo...

Objective-  To evaluate the role of autogenous bone marrow (BM), in the healing of experimentally induced burn wound in rats. Design- Experimental in-vivo study.   Animals- 20 adult male white New Zealand rabbits.   Procedures- Two burn wounds were created under general anesthesia using a 100 W electric soldering iron, heated to the point of redness (about 800° C) on each side of the back, 4...

Bone fractures usually happen during car accident and sport trauma. Different factors influence bone healing such as malnutrition and smoking. Apart from addiction which is an important individual, social, and cultural problems morphine has several effects on body physiology and immune system .This study is performed to assess the effect of morphine dependency on bone healing and has not been r...

Background Mandibular continuity defects occur after tumor resection, maxillofacial injury, or osteomyelitis. Despite the current availability of a plethora of treatment modalities, bone substitutes, and various clinical adjuncts, an exact reconstructive recapitulation of large bony defects continues to be beyond reach. In this clinical pilot study, we report a novel method for reconstruction ...

BACKGROUND Rotator cuff tears are a common source of pain and disability, and poor healing after repair leads to high retear rates. Bone loss in the humeral head before and after repair has been associated with poor healing. The purpose of the current study was to mitigate bone loss near the repaired cuff and improve healing outcomes. METHODS Sclerostin antibody (Scl-Ab) treatment, previously...

background mandibular continuity defects occur after tumor resection, maxillofacial injury, or osteomyelitis. despite the current availability of a plethora of treatment modalities, bone substitutes, and various clinical adjuncts, an exact reconstructive recapitulation of large bony defects continues to be beyond reach. in this clinical pilot study, we report a novel method for reconstruction o...

Titanium is biocompatible with bone tissue, and during the healing process bone makes intimate contact with the implant surface. Although much is known about the long-term healing of implants, less is known about the callus formation at implants. In this study, the histology of bone healing was studied during the period between 4 and 14 days. Incisions were made in rat tibia. Some incisions wer...

background: effects of estrogen on bone metabolism and its protective role on prevention of osteoporosis are well   documented. however, the efficacy of estrogen treatment on bone healing is not well investigated. the drug can be delivered both systemically or locally to the bone with differences in concentrations and side effects. the aim of this study was to investigate the effect of local an...

PURPOSE OF REVIEW Bone fracture healing is a complex physiological process relying on numerous cell types and signals. Inflammatory factors secreted by immune cells help to control recruitment, proliferation, differentiation, and activation of hematopoietic and mesenchymal cells. Within this review we will discuss the functional role of immune cells as it pertains to bone fracture healing. In d...

introduCtion: The healing capacity of bone can be substantially reduced by metabolic diseases such as diabetes mellitus. Apart from an epidemiological component of metabolic diseases the present poor therapy of diabetic associated bone healing deficiencies demands adequate new treatment options. In previous studies we were able to show a massive impairment of bone regeneration in diabetic bone....