The adaptive bone remodeling phenomenon in the femur before and after prosthetic total hip joint replacement (THR) was investigated using the three dimensional finite element method. A normal hip joint model which composed of the proximal femur and the pelvic bone including femoral head and acetabular was constructed three-dimensionally by our method reported previously. The simulation model wa...

During osteoporosis therapy with alendronate, esophagitis and stomach ulceration may occur, requiring the concurrent use of drugs which decrease gastric juice production. The aim of the present study was to investigate the effect of concurrent administration of proton pump (H+/K+ATP-ase) inhibitors: omeprazole or pantoprazole and alendronate on bone remodeling in ovariectomized rats. The experi...

BACKGROUND Damages to large arteries are related to bone disease in end-stage renal disease and contribute to cardiovascular mortality. An outward remodeling and stiffening of carotid artery already exist at an earlier stage of chronic kidney disease (CKD). We made the hypothesis that bone disease could be associated with the carotid outward remodeling in parallel with the decline of renal func...

Bone is a composite organ that fulfils several interconnected functions, which may conflict with each other in pathological conditions. Bone vascularization is at the interface between these functions. The roles of bone vascularization are better documented in bone development, growth and modeling than in bone remodeling. However, every bone remodeling unit is associated with a capillary in bot...

Bone biology and the molecular basis of normal bone remodeling are important for understanding bone health, particularly for medical professionals who are treating patients with skeletal complications. Key factors in bone remodeling include RANK ligand, which stimulates bone resorption, and osteoprotegerin (OPG), which inhibits bone resorption. The ratio between these two factors regulates oste...

This review describes normal bone anatomy and physiology as an introduction to the subsequent articles in this section that discuss clinical applications of iliac crest bone biopsy. The normal anatomy and functions of the skeleton are reviewed first, followed by a general description of the processes of bone modeling and remodeling. The bone remodeling process regulates the gain and loss of bon...

Bone remodeling Our current understanding is that postmenopausal osteoporosis results from a bone remodeling imbalance with bone resorption exceeding bone formation and that the medications approved for osteoporosis treatment all work by modulating bone remodeling in a favorable way. This is almost certainly correct, yet there is much more to be learned about bone remodeling that might enhance ...

Decreased physical activity in mammals increases bone turnover and uncouples bone formation from bone resorption, leading to hypercalcemia, hypercalcuria, bone loss and increased fracture risk. Black bears, however, are physically inactive for up to 6 months annually during hibernation without losing cortical or trabecular bone mass. Bears have been shown to preserve trabecular bone volume and ...

Bone remodeling is regulated by systemic and local factors, and glucocorticoids are hormones with a significant impact on the skeleton. Bone remodeling is tightly regulated, and bone formation occurs in areas of previously resorbed bone. Bone is continuously regenerated, a process that is carried out by basic multicellular units. These units are comprised by teams of juxtaposed osteoclasts and ...