background: the effective therapeutic dose of pralidoxime methylsulphate for organophosphate (op) poisoning is necessary to be clarified. this study was designed to comparatively assess the blood level of pralidoxime (bpl) and clinical outcomes in op poisoned patients treated with intermittent dosing and patients treated with continuous infusion. methods: this was a prospective, open labelled, ...

The bactericidal activity of 3-propiolactone (BPL) vapor was first reported by Hoffman and Warshowsky (1958). Although this chemical has shown promise in our laboratories as a very useful gaseous disinfectanit for rooms and buildings, the lack of information on the virucidal activity of BPL vapor has been a deterrent in the use of the chemical to decontaminate virology laboratories or buildings...

A 10% suckling rat brain rabies vaccine free from encephalitogenic activity was prepared and inactivated with 1:8,000 beta-propiolactone (BPL), or ultraviolet light, or a combination of ultraviolet light and BPL, or 1% phenol. Potency was excellent in all samples, with the exception of the phenolized product which was marginal. A purified suckling rat brain (SRB) vaccine prepared by zonal centr...

The bactericidal activity of 3-propiolactone (BPL) vapor was first reported by Hoffman and Warshowsky (1958). Although this chemical has shown promise in our laboratories as a very useful gaseous disinfectanit for rooms and buildings, the lack of information on the virucidal activity of BPL vapor has been a deterrent in the use of the chemical to decontaminate virology laboratories or buildings...

Hypertension is a complex trait with multiple genetic determinants. A previous genome-wide linkage study of systolic blood pressure in a mouse genetic backcross implicated a region of chromosome 13 (LOD = 3.3 at 16.0 cM) as a determinant of blood pressure differences between a hereditary low blood pressure strain of Mus musculus (BPL/1) and Mus spretus (SPRET); at this locus, the unexpected eff...

This paper considers broadband signal transmission via high-voltage/broadband over power lines (HV/BPL) channels associated with overhead power transmission. To determine the end-to-end channel characteristics of various overhead HV/BPL multiconductor transmission line (MTL) configurations, the chain scattering matrix or T -Matrix (TM) method is adopted. The overhead HV/BPL transmission channel...

This study was designed to improve the efficacy of radiation therapy against radiation-resistant leukemia. We report that the potency of low dose radiation therapy against B-precursor acute lymphoblastic leukemia (BPL) can be markedly enhanced by combining radiation with a liposomal nanoparticle (LNP) formulation of the SYK-P-site inhibitor C61 ("C61-LNP"). C61-LNP plus low dose total body irra...

There is a desperate need for novel antibiotic classes to combat the rise of drug resistant pathogenic bacteria, such as Staphylococcus aureus. Inhibitors of the essential metabolic enzyme biotin protein ligase (BPL) represent a promising drug target for new antibacterials. Structural and biochemical studies on the BPL from S. aureus have paved the way for the design and development of new anti...

Neo-fermented buckwheat sprouts (neo-FBS) contain angiotensin-converting enzyme (ACE) inhibitors and vasodilators with blood pressure-lowering (BPL) properties in spontaneously hypertensive rats (SHRs). In this study, we investigated antihypertensive mechanisms of six BPL peptides isolated from neo-FBS (FBPs) by a vasorelaxation assay and conventional in vitro, in vivo, and a new ex vivo ACE in...