it has been estimated that more than 1.7 million individuals suffer a traumatic brain injury (tbi) each year. tbi causes secondary biochemical and metabolic changes which contribute to subsequent tissue damage and associated neuronal cell death. two early and delayed events occur after tbi, which results in neurological deficits. primary injury events include the mechanical damage that occur at...

brain injury is a complex event leading to tissue damage and functional deficits by primary and secondary mechanisms. since the application of tissue engineering approaches is a new topic in the treatment of brain injury, producing a proper experimental model to evaluate the effects of tissue engineering products on damaged brain tissue is required. in the present study, a simple and reproducib...

motor vehicle and falling down are responsible for the most number of traumatic injuries. this study aimed to compare the characteristics of traumatic brain injury among accident and falling down cases. in this analytical cross- sectional study, data were collected from the records of cadavers who died due to accident or falling down and referred to kahrizak dissection hall, tehran forensic med...

objective(s):melatonin is known as an anti-inflammatory agent, and it has been proven to exert neuroprotection through inhibition of cell death (apoptosis) in several models of brain injury.secondary injury following the primary traumatic brain injury (tbi) results in glial cells activation, especially astrocytes. in fact, astrocyte activation causes the production of pro-inflammatory cytokines...

traumatic brain injury (tbi) is defined as an external mechanical injury to the brain. neuroinflammation plays a vital role in the pathophysiology of tbi. microglia and astrocytes play a central role in the initiation and regulation of inflammation. numerous pro-inflammatory mediators including cytokines, chemokines, reactive oxygen species (ros) and nitric oxide (no) released by microglia. in ...

intracranial hypertension is the largest cause of death in young patients with severe traumatic brain injury. decompressive craniectomy is part of the second level measures for the management of increased intracranial pressure refractory to medical management as moderate hypothermia and barbiturate coma. the literature lack of concepts is their indications. we present a review on the state of t...

cortical spreading depression (csd) are associated with dramatic failure of brain ion homeostasis, efflux of excitatory amino acids from nerve cells, increased energy metabolism and changes in cerebral blood flow. there is strong clinical and experimental evidence to suggest that csd is involved in the mechanism of migraine, stroke, subarachnoid hemorrhage and traumatic brain injury. therefore,...

continuous four hours eeg (electroencephalogram) recordings and its power spectrum analysis using fast fourier transform (fft) in urethane anesthetized male charles foster rats were performed in two groups: open brain injury and p-cpa (para-chlorophenylalanine) pretreated before brain injury, respectively, and compared with the eeg power spectrum of control rats. the eeg power spectrum analysis...

objective(s): preclinical studies show that iron plays a key role in mediating neuronal injury. this study was performedin order to identify the relationship between the serum level of ferritin and severity of the brain injury which occur after an intracerebral hemorrhage (ich). materials and methods:this was a cross sectional descriptive – analytic study, which was conducted on those patients ...

objective(s):this study was carried out to investigate the effects of cox-2 selective inhibitor (celecoxib) or non-selective cox inhibitor (ibuprofen) on gastrointestinal motility. materials and methods: the rats were randomly divided into five groups including: intact, sham, traumatic brain injury (tbi) group (intact rats under tbi), celecoxib group (10 mg/kg), ibuprofen group (10 mg/kg). rats...