Historical perspective A series of experiments done in the mid 1950s established the heart as an endocrine organ. First, Kisch and colleagues detected secretory granules in guineapig atria. Henry and Pearce subsequently described increased urinary flow after balloon stretch of the canine left atrium. In an experiment done 25 years later, de Bold injected homogenised atrial tissue into rats and ...

We have compared the expression of atria1 natriuretic peptide (ANP) and brain natriuretic peptide (BNP) genes in various human tissues using a quantitative polymerase chain reaction technique. Tissues of three human subjects, obtained at autopsy, were analyzed. BNP transcripts could be detected in the central nervous system, lung, thyroid, adrenal, kidney, spleen, small intestine, ovary, uterus...

To characterize the type of cell expressing natriuretic peptide receptors in the brain and the nature of these receptors, we conducted studies in primary cultured glial and neuronal cells derived from fetal rat diencephalon. The glial predominant cultures (95% of total cells and glial fibrillary acidic protein positive) expressed nearly a 10-fold greater specific binding of the natriuretic pept...

UNLABELLED In 1,049 patients with stable ischemic heart disease (IHD), brain natriuretic peptide (BNP) and amino terminal pro-brain natriuretic peptide (NTproBNP) correlated closely (r = 0.09, p < 0.001) and were similarly related to left ventricular ejection fraction (LVEF) (r = -0.50 and -0.46, respectively), age (0.44 and 0.47), and creatinine clearance (-0.51 and -0.51). Receiver-operating ...

We studied the presence of three natriuretic peptides--atrial natriuretic peptide (ANP), human brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP)--in the human kidney by radioimmunoassay and immunocytochemistry. Immunoreactive ANP, immunoreactive human BNP, and immunoreactive CNP concentrations in six kidneys were 0.12 +/- 0.07 (mean +/- SD), 0.23 +/- 0.08, and 0.37 +/- 0.07 ...

BACKGROUND In ischaemic cardiomyopathy, raised plasma concentrations of natriuretic peptides are associated with a poor long term prognosis, while the presence of contractile reserve is a favourable sign. OBJECTIVE To assess the relation between plasma natriuretic peptides and contractile reserve. DESIGN Prospective observational study. SETTING Tertiary referral centre. PATIENTS 66 cons...

Background: In ischaemic cardiomyopathy, raised plasma concentrations of natriuretic peptides are associated with a poor long term prognosis, while the presence of contractile reserve is a favourable sign. Objective: To assess the relation between plasma natriuretic peptides and contractile reserve. Design: Prospective observational study. Setting: Tertiary referral centre. Patients: 66 consecu...

b-type natriuretic peptide (bnp) level is known to increase in patients with rheumatic mitral stenosis. in this systematic review, we aimed to discuss the possible association between plasma bnp level and the success rate of percutaneous transvenous mitral commissurotomy. pubmed and scopus databases were searched systematically, using the following key terms: “b-type natriuretic peptide” or “bn...