نتایج جستجو برای: brainderived neurotrophic factor

تعداد نتایج: 846248  

Journal: :مجله علوم اعصاب شفای خاتم 0
ali jahanbazi jahan-abad shefa neuroscience research center, khatam alanbia hospital tehran, iran hassan hosseini ravandi shefa neuroscience research center, khatam alanbia hospital tehran, iran

long-term potentiation (ltp) is a process that certain types of synaptic stimulation lead to a long-lasting enhancement in the strength of synaptic transmission. studies in recent years indicate the importance of molecular pathways in the development of memory and learning. tropomyosin receptor kinase b (trkb) is a member of the neurotrophin receptor tyrosine kinase family, that its ligand is b...

Journal: :iranian journal of basic medical sciences 0
gulay hacioglu department of physiology, faculty of medicine, giresun university, turkey ayse senturk department of clinical biochemistry, faculty of medicine, karadeniz technical university, turkey imran ince department of clinical biochemistry, faculty of medicine, karadeniz technical university, turkey ahmet alver department of clinical biochemistry, faculty of medicine, karadeniz technical university, turkey

objective(s): exposing to stress may be associated with increased production of reactive oxygen species (ros). therefore, high level of oxidative stress may eventually give rise to accumulation of oxidative damage and development of numerous neurodegenerative diseases. it has been presented that brain-derived neurotrophic factor (bdnf) supports neurons against various neurodegenerative conditio...

Journal: :The European journal of neuroscience 2003
Elin Gustafsson Gunnar Andsberg Vladimer Darsalia Paul Mohapel Ronald J Mandel Deniz Kirik Olle Lindvall Zaal Kokaia

To explore the role of brain-derived neurotrophic factor for survival and generation of striatal neurons after stroke, recombinant adeno-associated viral vectors carrying brain-derived neurotrophic factor or green fluorescent protein genes were injected into right rat substantia nigra 4-5 weeks prior to 30 min ipsilateral of middle cerebral artery occlusion. The brain-derived neurotrophic facto...

Journal: :Development 1993
G Dechant S Biffo H Okazawa R Kolbeck J Pottgiesser Y A Barde

Previous studies using transfected cells have indicated that the mammalian receptor tyrosine kinase trkB binds the neurotrophins brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4. However, most studies demonstrating that these neurotrophins prevent the death of embryonic neurons and have specific neuronal receptors have been performed with chick neurons. In order to explore t...

1999
S. D. CROLL H. E. SCHARFMAN

Transgenic mice overexpressing brain-derived neurotrophic factor from the b-actin promoter were tested for behavioral, gross anatomical and physiological abnormalities. Brain-derived neurotrophic factor messenger RNA overexpression was widespread throughout brain. Overexpression declined with age, such that levels of overexpression decreased sharply by nine months. Brain-derived neurotrophic fa...

2017
Tuane Bazanella Sampaio Anne Suely Savall Maria Eduarda Ziani Gutierrez Simone Pinton

Neurotrophic factors comprise essential secreted proteins that have several functions in neural and non-neural tissues, mediating the development, survival and maintenance of peripheral and central nervous system. Therefore, neurotrophic factor issue has been extensively investigated into the context of neurodegenerative diseases. Alzheimer's disease and Parkinson's disease show changes in the ...

2014
Nazem Ghasemi Shahnaz Razavi

Adipose-derived stem cells are a kind of mesenchymal stem cells which have a higher frequency in the adipose tissue and can be harvested by minimally invasive procedures. These cells are able to differentiate into other cells outside their lineage such as neuron, neurotrophic factor secreting cells and Schwann cells. Many of the identified neurotrophic factors such as brain-derived neurotrophic...

2016
Elin Gustafsson Gunnar Andsberg Vladimer Darsalia Paul Mohapel Ronald J. Mandel Deniz Kirik Olle Lindvall Zaal Kokaia

To explore the role of brain-derived neurotrophic factor for survival and generation of striatal neurons after stroke, recombinant adenoassociated viral vectors carrying brain-derived neurotrophic factor or green fluorescent protein genes were injected into right rat substantia nigra 4–5 weeks prior to 30 min ipsilateral of middle cerebral artery occlusion. The brain-derived neurotrophic factor...

Journal: :Neuroscience 1999
S D Croll C Suri D L Compton M V Simmons G D Yancopoulos R M Lindsay S J Wiegand J S Rudge H E Scharfman

Transgenic mice overexpressing brain-derived neurotrophic factor from the beta-actin promoter were tested for behavioral, gross anatomical and physiological abnormalities. Brain-derived neurotrophic factor messenger RNA overexpression was widespread throughout brain. Overexpression declined with age, such that levels of overexpression decreased sharply by nine months. Brain-derived neurotrophic...

2014
Jie Du Xiaoqing Gao Li Deng Nengbin Chang Huailin Xiong Yu Zheng

Glial cell line-derived neurotrophic factor recombinant adenovirus vector-transfected bone marrow mesenchymal stem cells were induced to differentiate into neuron-like cells using inductive medium containing retinoic acid and epidermal growth factor. Cell viability, microtubule-associated protein 2-positive cell ratio, and the expression levels of glial cell line-derived neurotrophic factor, ne...

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