نتایج جستجو برای: brevinin
تعداد نتایج: 59 فیلتر نتایج به سال:
The volume is dedicated to novel anticancer strategies. Our aim was to identify and cover novel, emerging anticancer approaches that will form the backbone of future, more efficient anticancer therapies. Beside classical "small molecule" pharmacologic approaches, or radiotherapy, the review introduces cancer stem cell, their markers involved in metastasizing, it covers various immunotherapeutic...
Antimicrobial peptides (AMPs) are regarded as promising alternatives for antibiotics due to their inherent capacity to prevent microbial drug resistance. Amphibians are rich source of bioactive molecules, which provide numerous AMPs with various structures as drug candidates. Here, we isolated and identified a novel AMP Brevinin-2Ta (B-2Ta) from the skin secretion of the European frog, Pelophyl...
پپتیدهای ضد میکروبی با هدف قرار دادن غشا سبب از بین سلولهای میکروبی می شوند. این پپتید ها خاصیت دوگانه دوست دارند به طوری که بخش آبگریز آنها داخل غشا و بخش باردار آنها با فسفولیپیدها بر هم کنش می دهد.پپتید brevenin-2r از ترشحات پوست قورباغه rana ridibunda بدست آمد. این پپتید دارای 25 آمینواسید است. مطالعات ساختاری بوسیله cd نشان داد که این پپتید در محیط آبی بدون ساختار ودر محیط های آب گریز ساخت...
Classical chemotherapy, that spocifically targets rapidly proliferating cells, has been in existence for over eighty yeors and has proven to be fully successful in only a limited number of cancers. Thus, this review focuses on a novel, emerging approach for cancer therapy that uses alternative, a nd more unique features of cancer cells. This new approach faci litates the seloctive targeting of ...
This study investigated the ability of anaerobic periodontal bacteria to inactivate and resist killing by antimicrobial peptides through production of extracellular proteases. Antibacterial activities of peptides were assessed in a double-layer agarose diffusion assay, and MICs and MBCs were determined in broth microdilution assays. Culture supernates of Porphyromonas gingivalis and Prevotella ...
Abstract Background Batrachochytrium dendrobatidis ( Bd ) is the causative agent of chytridiomycosis, one major causes worldwide amphibian biodiversity loss. Many amphibians exhibit skin-based chemical defences, which may play an important role against invading pathogens, but whether synthesis these compounds enhanced or suppressed in presence pathogens largely unknown. Here we investigated dir...
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