Since the Human Genome Project was completed, much attention has been given to genome technologies to regulate target gene expression or function. The most simple and promising approach to down-regulate target gene expression in a living cell is antisense strategy, which prevents translation by hybridization of an oligonucleotide with its complementary RNA strand. For practical use in antisense...

The role of thiophene bridges in determining the photophysical properties of bridged core-modified hexaphyrins is investigated. Depending on the substituted chalcogen atoms and conjugational perturbation across the thiophene bridges, the bridged core-modified hexaphyrins reveal unique photophysical properties.

The E-4,4'-bis[di(p-anisyl)amino]stilbene cation is a class-III mixed-valence species with electronic coupling comparable to that in its biphenyl-bridged analogue, whereas its tolane-bridged analogue belongs to class II.

A series of 8 new complexes of titanium and zirconium with diamido ligands bearing an ethylene and propylene bridge between the two amido groups were synthesized and tested for ethylene polymerization. Titanium complexes bearing an ethylene bridge between the two amido groups showed higher activities than the derivatives with a propylene bridge. In the case of the zirconium complexes, the p...

Modified nucleosides have the potential to inhibit DNA polymerases for the treatment of viral infections and cancer. With the hope of developing potent drug candidates by the modification of the 2',4'-position of the ribose with the inclusion of a bridge, efforts were focused on the inhibition of Taq DNA polymerase using quantitative real time PCR, and the results revealed the significant inhib...

A series of bridged bis(beta-cyclodextrin(CD))s (2-7) were synthesized, i.e., bridged bis(beta-CD)s 2 and 3 bearing binaphthyl or biquinoline tethers and bridged bis(beta-CD)s 4-7 possessing dithiobis(benzoyl) tether, and their complex stability constants (KS), enthalpy (DeltaH degrees), and entropy changes (DeltaS degrees) for the 1:2 inclusion complexation with representative steroids, deoxyc...

The highly reactive, six-coordinate tris-aryloxide U(III) species, [((t-BuArO)3tacn)U] (1) reacts with CO2 in a 2e- reduction to produce CO and a dinuclear U(IV/IV) mu-oxygen bridged complex [{((t-BuArO)3tacn)U}2(mu-O)] (2). This reaction proceeds via a dinuclear CO2-bridged intermediate 3. Also, mononuclear 1 was treated with 1 atm of CO to yield dinuclear [{((t-BuArO)3tacn)U}2(mu-CO)] (4) wit...

Abstract. Porphyrin rings containing two meso-pyridyl groups either in cis or trans fashion can be used to construct Re(I) bridged multiporphyrin assemblies. The cis-dipyridyl porphyrins with various porphyrin cores such as N4, N3O, N3S, N2S2 have been used to react with Re(CO)5Cl in THF at refluxing temperature and constructed planar Re(I) bridged porphyrin dyads containing either one type of ...

The CXCR4 chemokine receptor is implicated in a number of diseases including HIV infection and cancer development and metastasis. Previous studies have demonstrated that configurationally restricted bis-tetraazamacrocyclic metal complexes are high-affinity CXCR4 antagonists. Here, we present the synthesis of Cu(2+) and Zn(2+) acetate complexes of six cross-bridged tetraazamacrocycles to mimic t...

In the polymeric title compound, [Cu(3)W(2)(CN)(16)(C(7)H(6)N(2))(6)(H(2)O)](n), the coordination geometry of the W(V) atom is eight-coordinate dodeca-hedral, where four CN groups of [W(CN)(8)] are bridged to Cu(II) ions, and the other four CN groups are not bridged. The coordination geometries of the Cu(II) ions are five-coordinate pseudo-square-based pyramidal. There are two distinct Cu sites...