Ion channels are protein macromolecules that form biological nanotubes across the membranes of living cells. Given many possible geometrical shapes of an ion channel, we propose a computational scheme of selecting the model that best replicates experimental observations, using adaptive Brownian dynamics simulations together with discrete optimization algorithms. Brownian dynamics simulations em...

We report the breaking of ergodicity for a class of generalized, Brownian motion obeying a non-Markovian dynamics being driven by a generalized Langevin equation (GLE). This very feature originates from a vanishing of the effective friction. A novel quantity b (being uniquely determined from the corresponding memory friction kernel gamma(t)of the GLE) is introduced as a parameter that is capabl...