Multiple myeloma (MM) is a clonal B-cell malignancy characterized by an accumulation of clonal plasma cells in the bone marrow leading to bone destruction and bone marrow failure. Several molecular mechanisms underlie chemoresistance among which heme oxygenase-1 (HO-1) could play a major role. The aim of the present research was to evaluate the impact of HO-1 in MM following bortezomib (BTZ) tr...

We introduce a set of scalar fields as test fields to study the dynamical behaviors of the BTZ(Banados-Teitelboim-Zanelli) black hole. These include minimally coupled scalar, conformally coupled scalar, and dilaton. To calculate the decay rate of the BTZ black hole, we consider both the Dirichlet boundary condition at spatial infinity and the matching procedure. It turns out that the dilaton is...

The greybody factors for spin 1 2 particles in the BTZ black holes are discussed from 2D CFT in bulk-boundary correspondence. It is found that the initial state of spin 1 2 particle in the BTZ black holes can be described by the Poincaré vacuum state in boundary 2D CFT, and the nonlinear coordinate transformation causes the thermalization of the Poincaré vacuum state. For special case, our resu...

Primary effusion lymphoma (PEL) is a rare form of aggressive B cell lymphoma caused by Kaposi's sarcoma-associated herpesvirus (KSHV). Current chemotherapy approaches result in dismal outcomes, and there is an urgent need for new PEL therapies. Previously, we established, in a direct xenograft model of PEL-bearing immune-compromised mice, that treatment with the proteasome inhibitor, bortezomib...

This paper has two parts. First we review the description of local bulk operators in Lorentzian AdS in terms of non-local operators in the boundary CFT. We discuss how bulk locality arises in pure AdS backgrounds and how it is modified at finite N . Next we present some new results on BTZ black holes: local operators can be defined inside the horizon of a finite N BTZ black hole, in a way that ...

We study AdS/CFT correspondence in the case of AdS3. We obtain the statistical entropy of the BTZ black hole in terms of the correct central charge and the conformal dimensions for the states corresponding to the BTZ black hole. We point out the difference between our method and the old fashioned approaches based on SL(2, R) Wess-Zumino-Witten model or Liouville theory. email: [email protected] e...

Hawking radiation is viewed as a tunnelling process. In this way the effect of selfgravitation gives rise to quantum corrections to the entropy of the (2+1) BTZ black hole. The modified entropy, due to specific modelling of the self-gravitation effect, of the (2+1) BTZ black hole is evaluated. To first order in ω which is a shell of energy radiated outwards the event horizon of the BTZ black ho...

This paper has two parts. First we review the description of local bulk operators in Lorentzian AdS in terms of non-local operators in the boundary CFT. We discuss how bulk locality arises in pure AdS backgrounds and how it is modified at finite N . Next we present some new results on BTZ black holes: local operators can be defined inside the horizon of a finite N BTZ black hole, in a way that ...

This paper has two parts. First we review the description of local bulk operators in Lorentzian AdS in terms of non-local operators in the boundary CFT. We discuss how bulk locality arises in pure AdS backgrounds and how it is modified at finite N . Next we present some new results on BTZ black holes: local operators can be defined inside the horizon of a finite N BTZ black hole, in a way that ...