The synthesis of a Pd–NHC cinnamyl-complex supported on calix[8]arene and its use in Buchwald–Hartwig amination is reported. Thanks to the support, products were isolated with low levels residual palladium, some cases below standards.

A new [2.2]paracyclophane-based electron-rich and sterically bulky monophosphine ligand has been synthesized by an efficient and straightforward method. When combined with palladium, this ligand shows excellent performance in the Buchwald-Hartwig amination and Suzuki-Miyaura coupling reactions of various aryl chlorides. In both types of reactions, ortho-substituted, deactivated aryl chlorides a...

Halogenated quinazolinones and quinazolines are versatile synthetic intermediates for the metal-catalyzed carbon-carbon bond formation reactions such as the Kumada, Stille, Negishi, Sonogashira, Suzuki-Miyaura and Heck cross-coupling reactions or carbon-heteroatom bond formation via the Buchwald-Hartwig cross-coupling to yield novel polysubstituted derivatives. This review presents an overview ...

Two divergent synthetic routes are reported offering access to four quinolone natural products from Pseudonocardia sp. CL38489. Key steps to the natural products involved a regioselective epoxidation, an intramolecular Buchwald-Hartwig amination and a final acid-catalysed 1,3-allylic-alcohol rearrangement to give two of the natural products in one step. This study completes the synthesis of all...

During thelast20-30 years, palladium-catalyzed reactions have witnessed tremendous advances in the industrial and organic reactions such as hydrogenation, coupling, cyanation and amination. Despite the wide utility of Pd-catalysts in these reactions, they suffer from a number of drawbacks such as recovery, reuse of catalyst and remain as  a contaminant in the products at the end of the reaction...

The preparation of (hetero)arylamines has been significantly advanced by developments in transition metal-catalyzed Csp2–N coupling (e.g., Buchwald–Hartwig, Chan–Lam, and Ullmann couplings). As a complement to these strategies, our group recently demonstrated the reductive arylboronic acids nitro compounds, initially nitro(hetero)arenes more nitromethane, an organophosphorus-catalyzed method op...