1 Central Animal Facility, Indian Institute of Science, Bangalore-560 012, India. 2 Anjuman Arts, Sciences & Commerce College, Bijapur-586101, India. 3 Research Centre, Electron Microscope Unit, # 5, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Kingdom of Saudi Arabia. 4 Centre for Sustainable Technologies, Indian Institute of Science, Bangalore-560 012, India. * Corre...

Results There were 19 patients with FMF (13 F/6 M) who were receiving canakinumab for various indications. Here we report 10 (6 F/4 M) who had at least 3 injections. Three patients had concomitant diseases such as psoriasis, ankylosing spondylitis and polyarteritis nodosa. The indications for canakinumab (150mg) were colchicine resistancy in 7 patients (>1 attack/month), amyloidosis in 2 and in...

Recent advances in achieving highly durable clinical responses via inhibition of immune checkpoint proteins including CTLA-4 and PD1 have revolutionized the outlook for cancer therapy. However, along with impressive clinical activity (response rate of ~25% with either antiCTLA-4 or anti-PD1 as single agent, but > 50% with a combination), severe immune-related adverse events (irAEs) due to the b...

[1]. Departamento de Patologia e Medicina Legal, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE. [2]. Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Fortaleza, CE. [3]. Departamento de Farmácia, Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Fortaleza, CE. [4...

A number of chemicals including antioxidants, vitamins and hormones are widely advertised as anti-aging drugs (geroprotectors). It is usually believed that life-extending capacity of geroprotectors may be attributed to their specific anti-aging mechanisms, even without solid scientific evidence. The analysis of the survival data gathered by both anti-aging and hormetic interventions demonstrate...

Ordered sequences of univariate or multivariate regressions provide statistical models for analysing data from randomized, possibly sequential interventions, from cohort or multi-wave panel studies, but also from cross-sectional or retrospective studies. Conditional independences are captured by what we name regression graphs, provided the generated distribution shares some properties with a jo...