Increasing evidences indicate that shikonin can suppress the tumor growth. However, the mechanisms remain elusive. In the present study, we investigated the effects and mechanisms of shikonin against esophageal cancer. The expression of hypoxia inducible factor 1α (HIF1α) and pyruvate kinase M2 (PKM2) in esophageal cancer tissues and cells was detected by immunohistochemistry and Western blot. ...

esophageal cancer is one of the most common malignancies in our country. patients often seek medical advice in advanced and inoperable stages or with cervical esophageal cancer, in which operation is accompanied by sever morbidity. in this conditions many of them cannot tolerate chemo-radiation, or refuse it. therefore radiotherapy is applied as a single modality in palliation of many patients ...

Introduction: Cancer is one of the main causes for mortality and morbidity in the world. Identifying epidemiology and the trend of esophageal cancer may be highly effective in related planning. The present study has been carried out with the aim of exploring the morbidity and trend of esophageal cancer in Iran. Methods: The present study is a type of repe...

introduction: as one of the most common cancers among head and neck malignancies, cancer of the oral cavity probably has some variations in countries with a high prevalence of esophageal cancer.  materials and methods: patients with oral cavity cancer who were treated at two tertiary referral centers from january 1999 to january 2009 were included in this study. in addition to demographic data,...

background: lactoferrin (lf) is a glycoprotein, a member of the transferrin family.from ten known mechanisms of anti-cancer chemoperotecive compounds, lf alone, has six of these functions and inhibits cancer. in this study, the effect of lactoferrin purified from bovine colostrum was studied as an anti-cancer agent on esophageal cancer cell line. materials and methods: bovine colostrum were col...

introduction: esophageal and gastric cancers are among the most common cancers in iran. usually survival of these cases is poor despite of treatment. here we studied outcome of these cases in our center to have an estimation of general prognosis of patients. methods: in this retrospective study, we reviewed the data of patient's files before treatment, including cancer stage at diagnosis, types...

The global burden of cancer is increasing; this is considered to be largely because of change in life-style, an increasing adoption of cancer-causing behaviors and exposure to carcinogens in the environment. Based on IARC statistics, 12.7 million cancer cases are diagnosed and 7.6 million cancer deaths are estimated world-wide (Ferlay et al., 2008). Esophageal cancer is the sixth most common ca...

abstract background: esophageal anastomosis leaks continue to be a significant cause of morbidity and mortality after esophagectomy. the purpose of the present study was to identify the predisposing factors of esophageal anastomotic leakage. materials and methods: 95 patients who underwent surgical resection for esophageal or cardia cancer were included for the study. the mean age of the patien...

background: although breast cancer imposes a considerable economic burden on high-income countries, there is limited knowledge about its economic burden in low- and middle-income countries (lmcs), including iran. in this study, we estimated the economic burden of breast cancer in iran in 2010. methods: we used the prevalence-based approach and estimated the direct and indirect costs of all brea...