In this study the role of glutathione (GSH) in sulfur mustard -induced oxidative stress and cytotoxicity, in human skin fibroblast cell line (HF2FF) was evaluated. Sulfur mustard-induced superoxide radical and hydrogen peroxide formation were evaluated by determination of superoxide dismutase and catalase activity in cell lysate. The cytotoxicity of sulfur mustard was estimated by lactate dehyd...

Abstract Chiral hypervalent iodine reagents are active players in modern stereoselective organic synthesis. Structurally diverse chiral have been synthesised and extensively studied, but containing sulfur stereogenic centre scarce their synthesis is challenging. A small library of iodoarenes sulfinamide sulfoximine moieties has using commercially available reagents. The oxidation the iodoarene ...

The project started in 1982 with a Feasibility Study funded by the Commission of the European Community (Hutchins, 1986, pp. 287 291). Since 1984, the government of the Netherlands and BSO each support 50 % of the project. Annual budget averaged around 1 million dollar for the last three years, and still 5 million has been reserved for 1988-1991. Commercialization is not expected to begin befor...

USE OF METHIONINE SULFOXIMINE TO DISSECT THE ROLE OF GLUTAMINESYNTHETASE AND GLUTAMINE IN PROGRESSION OF ACUTE LIVER FAILUREby

Oxidative stress modulates angiotensin (Ang) II type 1 receptor (AT(1)R) expression and function. Ang II activates renal Na(+)/H(+) exchanger 3 (NHE3) to increase sodium reabsorption, but the mechanisms are still elusive. In addition, the upregulation of AT(1)R during oxidative stress could promote sodium retention and lead to an increase in blood pressure. Herein, we investigated the mechanism...

In hepatic S9 and human liver microsomes (HLMs) the sulfoximine moiety of the ATR inhibitor AZD6738 is metabolized to its corresponding sulfoxide (AZ8982) and sulfone (AZ0002). The initial deimination to AZ8982 is nominally a reductive reaction, but in HLMs it required both NADPH and oxygen and also was inhibited by 1-aminobenzotriazole at a concentration of 1 mM. Studies conducted in a panel o...