BACKGROUND A number of studies have reported relationships of CYP2E1 RsaI/PstI polymorphisms with susceptibility to lung cancer in Chinese population. However, the epidemiologic results have been conflictive rather than conclusive. The purpose of this study was to address the associations of CYP2E1 RsaI/PstI polymorphisms with lung cancer risk in Chinese population comprehensively. MATERIALS ...

C1 inhibitor of serine proteases (C1-INH) performs a regulatory function in the complement system and vascular permeability. Deficiency C1-INH leads to various forms angioedema, including hereditary angioedema (HAE). The cause HAE is genetically determined violation synthesis C1-INH. A decrease level 50% relative norm an increase production bradykinin, which basis for diagnosis HAE. development...

Kupffer cells (KC) represent the main part of the tissue macrophages. Beside phagocytosis of particulate material, involvement of KC in immunological and inflammatory reactions has been supposed. As C1 esterase inhibitor (C1-INH) is a serine protease inhibitor involved in such processes, the aim of this work was to study C1-INH synthesis in KC and, by comparison, in peritoneal macrophages (PM) ...

Let C1, C2 be Cantor sets embedded in the real line, and let τ1, τ2 be their respective thicknesses. If τ1τ2 > 1, then it is well known that the difference set C1 − C2 is a disjoint union of closed intervals. B. Williams showed that for some t ∈ int(C1−C2), it may be that C1∩ (C2 + t) is as small as a single point. However, the author previously showed that generically, the other extreme is tru...

Bacteriophage P1 encodes several regulatory elements for the lytic or lysogenic response, which are located in the immC, immI, and immT regions. Their products are the C1 repressor of lytic functions with the C1 inactivator protein Coi, the C4 repressor of antirepressor synthesis and the modulator protein Bof, respectively. We have studied in vitro the interaction of the components of the immC ...

We show that logic C1 cannot be extended to a paraconsistent logic in which the substitution theorem is valid. We show with the help of an answer set programming (ASP) tool called clasp, that C1 is robust with respect to certain three valued paraconsistent logics with some desirable properties. In particular C1 is robust with respect to three-valued logic P2, a logic for which some of the De Mo...

Hereditary angioedema resulting from the deficiency of the C1 inhibitor (HAE-C1-INH) is a rare, but potentially life-threatening disorder characterized by paroxysmal episodes of subcutaneous or submucosal edema. Early diagnosis is essential. Management is aimed at the prompt elimination of full-fledged attacks, as well as at the prevention of edematous episodes. The most straightforward means f...

RasGRPs (guanine-nucleotide-releasing proteins) are exchange factors for membrane-bound GTPases. All RasGRP family members contain C1 domains which, in other proteins, bind DAG (diacylglycerol) and thus mediate the proximal signal-transduction events induced by this lipid second messenger. The presence of C1 domains suggests that all RasGRPs could be regulated by membrane translocation driven b...