نتایج جستجو برای: calcitonin gene related peptide
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Calcitonin gene-related peptide is a potent vasodilator neuropeptide that is localized in perivascular sensory nerves. To determine whether alpha-calcitonin gene-related peptide possesses protective activity against hypertension-induced end organ damage, hypertension was induced in alpha-calcitonin gene-related/calcitonin peptide knockout and wild-type mice by uninephrectomy, deoxycorticosteroi...
The calcitonin/calcitonin gene-related peptide gene expresses two different mRNAs by tissue-specific alternative processing. The calcitonin mRNA is produced in thyroid C cells by splicing of the first three exons to the fourth polyadenylated exon. It encodes a protein precursor containing an amino-terminal peptide, calcitonin, and a carboxyl-terminal peptide (CCP I). Calcitonin gene-related pep...
Introduction Calcitonin-gene-related peptide (CGRP) is a 37-amino acid neuropeptide which was first identified in 1982 as a product of the calcitonin gene derived by alternative splicing [ 11. This original peptide is now referred to as a-CGRP; a second gene, unrelated to calcitonin, produces P-CGRP [2]. These two forms are closely related in both rat and man (Figure l ) , and are widely distri...
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