A single-dose, prospective, randomized, four-treatment, four-period crossover study was conducted to determine the acute effect of therapeutically equivalent doses of three commonly used phosphate binders on oral iron absorption. Twenty-three healthy subjects received 65 mg of elemental iron alone and with each phosphate binder (calcium carbonate 3000 mg, calcium acetate 2668 mg, or sevelamer H...

Treatment of HL-60 cells with thapsigargin, a microsomal Ca2+/ATPase inhibitor, led to depletion of intracellular calcium stores followed by capacitative calcium entry. Stimulation of adenylyl cyclase with forskolin enhanced thapsigargin-induced Ca2+ influx. The forskolin effect was confirmed by enhanced fluorescence quenching induced by Mn2+ entry into fura-2 loaded cells. 1,9-Dideoxy-forskoli...

Chronic exposure to lead (Pb) affects neural functions in central nervous system (CNS) particularly the learning and memory. On the other hand, alteration of calcium level in the CNS results in activation of NOS. It has been shown that lead enters the neurons through calcium channels and displaces Ca2+ from calcium binding proteins such as calmodulin and troponin C thereby affecting calcium-med...

BACKGROUND AND OBJECTIVES Hyperphosphatemia and subclinical endotoxemia are important sources of inflammation in HD. Proinflammatory cytokines are strong correlates of soluble CD14 (sCD14) concentrations, an independent predictor of mortality in this population. We evaluated the effects of calcium acetate and sevelamer hydrochloride on serum inflammatory profile, endotoxin concentrations, and s...

Concrete specimens were exposed to weekly cycles of wetting and drying in distilled water and in solutions of sodium chloride, calcium chloride, magnesium chloride, and calcium magnesium acetate with either a 6.04 molal ion concentration, equivalent in ion concentration to a 15% solution of NaCl, or a 1.06 molal ion concentration, equivalent in ion concentration to a 3% solution of NaCl, for pe...

AIMS To clarify the role of acetate in neurochemical mechanisms of the initial (inborn) tolerance to ethanol. METHODS Rats with low and high inborn tolerance to hypnotic effect of ethanol were used. In the brain region homogenates (frontal and parietal cortex, hypothalamus, striatum, medulla oblongata) and brain cortex synaptosomes, the levels of acetate, acetyl-CoA, acetylcholine (AcH), the ...

In this study, calcium oxide (CaO) was used as an additive to form pores in a cellulose acetate (CA) and at the same time improve thermal stability of acetate. When CA/CaO membrane exposed water pressure, CA matrix area plasticized by CaO particles became weakened channels were formed. addition, high melting point its bonding with carbonyl group caused crosslinking effect. We succeeded manufact...

The effects of calcium and magnesium acetates on the formation of injection site and testicular tumors in male Wistar rats over 2 years following s.c. injections of cadmium chloride (CdCl2) were determined. The rats (25/group) received a single s.c. dose of CdCl2 (0.02 or 0.04 mmol/kg; 0.9% NaCl solutions). Calcium and magnesium acetates were administered as 3% dietary supplements for 2 weeks p...