We isolated and characterized three genes, crcA, cspE and crcB, which when present in high copy confer camphor resistance on a cell and suppress mutations in the chromosomal partition gene mukB. Both phenotypes require the same genes. Unlike chromosomal camphor resistant mutants, high copy number crcA, cspE and crcB do not result in an increase in the ploidy of the cells. The cspE gene has been...

Oxy-ferrous substrate-bound cytochrome P-450cam (mrsO2) autooxidizes in the absence of its specific effector protein, putidaredoxin, without hydroxylating the substrate, camphor. The autooxidation is first order with an activation energy of 17 kcal mol-1 at 25 degrees, pH 7.0. Substrate removal and low pH accelerate the reaction. The product, 5-exo-OH camphor, and a nonhydroxylated pseudosubstr...

This study analyzes the main aspects of the non-clinical profile of D-Camphor, a natural product widely used as a common remedy for several symptoms. The pharmacology, pharmacokinetics and toxicity of this substance are analyzed, with regard to all the literature available, in order to assess a risk profile and better understand the positive and negative aspects connected with its use. The gene...

This study analyzes the main aspects of the non-clinical profile of D-Camphor, a natural product widely used as a common remedy for several symptoms. The pharmacology, pharmacokinetics and toxicity of this substance are analyzed, with regard to all the literature available, in order to assess a risk profile and better understand the positive and negative aspects connected with its use. The gene...

BACKGROUND The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) and the Medical Outcomes Study Short Form 36 (SF-36) are widely used to assess patient-reported outcome in individuals with pulmonary hypertension (PH). The aim of the study was to compare the psychometric properties of the two measures. METHODS Participants were recruited from specialist PH centres in Australia and New ...

Bioassays were conducted to study the effectiveness of selected chemicals to prevent the multicolored Asian lady beetle, Harmonia axyridis (Pallas), from overwintering in buildings. We discovered that certain monoterpenoids elicited avoidance in adults toward treated Þlter paper within a petri dish bioassay at 1.0 mg/cm. Camphor and menthol were the most effective of the monoterpenoids tested. ...

The red imported fire ant (RIFA) Solenopsis invicta Buren causes severe damage to humans and animals as well as the environment. Chemical treatment is the main strategy of RIFA management, which also is potentially toxic to the environment. Plant essential oils (EOs) are considered as potential substance that can be used to control insects. This study aimed to identify the chemical composition ...

The coupling between deformation and motion in a self-propelled system has attracted broader interest. In the present study, we consider an elliptic camphor particle for investigating the effect of particle shape on spontaneous motion. It is concluded that the symmetric spatial distribution of camphor molecules at the water surface becomes unstable first in the direction of a short axis, which ...

Introduction Camphor is used as a proprietary preparation, most often as a 20% solution in arachis oil, and is applied to the skin for the supposed relief of muscle pain and symptoms of the common cold. Intoxication is usually accidental and, although reports are rare, Silbert (1973) drew attention to the risk of camphor poisoning in children. Symptoms following ingestion include tremors, hallu...

In our earlier studies of mixed function oxidation the bicyclic monoterpene (+)-camphor (24) was used as enzyme inducer and carbon source for growth of Pseudomonas putida,1 strain Cr. The reaction sequence formulated for camphor oxidation (5) is indicated in Fig. 1: I + II + III + VII + IX ---f X with IV as a side product. A cell extract of strain C1 also forms 1,2-campholide (V) from camphor (...