Microorganisms play a major role in the initiation and perpetuation of pulpal and periapical disease. In order to predictably achieve a bacteria-free root canal system, it is necessary to use intracanal medicaments. Calcium hydroxide [Ca(OH)(2)] is the most common intracanal medicaments. It is effective against primary infections. However, its effectiveness against Enterococcus (E.) faecalis an...

Biofilms and microbial aggregates are the common mechanisms for the survival of bacteria in nature. In other words, the ability to form biofilms has been regarded as a virulence factor. Microbial biofilms play an essential role in several infectious diseases such as pulp and periradicular pathosis. The aim of this article was to review the adaptation mechanisms of biofilms, their roles in pulpa...

INTRODUCTION The purpose of this in vitro study was to evaluate the effect of calcium hydroxide, double and triple antibiotic paste on the sealing ability of mineral trioxide aggregate (MTA) apical plugs. METHODS AND MATERIALS A total of 90 extracted teeth with single canals were prepared and randomly divided into four experimental groups (n=20). Intra-canal medicaments were applied for 3 wee...

Removal of bacterial biofilm from the root canal system is essential for the management of endodontic disease. Here we evaluated the antibacterial effect of N-acetylcysteine (NAC), a potent antioxidant and mucolytic agent, against mature multispecies endodontic biofilms consisting of Actinomyces naeslundii, Lactobacillus salivarius, Streptococcus mutans and Enterococcus faecalis on sterile huma...

Context One of the important goals of root canal therapy is disinfection aided by irrigation and intracanal medicaments. Commonly used nonsteroidal anti-inflammatory agents have shown anti-bacterial activity, thus, when used as intracanal medicaments, nonantibiotic agents have the potential to provide anti-inflammatory, local analgesic, and anti-bacterial activity. Aim The aim of this study i...

Purpose: To evaluate the bond strengths of two different types of resin luting cements to dentin treated with chemical irrigants and medicaments for root canal treatment. Materials and Methods: The bovine incisors were ground with silicon carbide paper to expose a dentin. Dentin surface was treated with either 3% hydrogen peroxide (H2O2), 5% sodium hypochlorite (NaOCl), the combination of H2O2 ...

OBJECTIVES Residual microorganisms in the root canal system (RCS) after endodontic therapy such as Candida albicans are a major cause of endodontic failure. Calcium hydroxide (CH) and chlorhexidine (CHX) have suitable antimicrobial activity against bacteria and can be used as intracanal medicaments. Nanosilver has also shown antimicrobial activity against microorganisms. This study aimed to com...

The aim of this study was to evaluate in vitro antimicrobial activity of 4 antibiotic agents (for E.faecalis) and 4 antifungal agents (for C.albicans) by agar dilution method. Additionally, modified strip diffusion method was used for detection of in vitro antimicrobial activities of 5% NaOCl, 2.5% NaOCl, 17% EDTA and 2% CHX and agar diffusion method for detection of in vitro susceptibilities o...

OBJECTIVE The objective was to investigate the effect of intracanal antibiotic medicaments followed by ethylenediaminetetraacetic acid (EDTA) on the indentation properties and hardness of radicular dentin using a BioDent reference point indenter and a traditional microhardness technique, respectively. MATERIALS AND METHODS Specimens with intact root canal dentin surfaces and polished radicula...

BACKGROUND To investigate the antifungal activity of propolis, triple antibiotic paste (TAP), 2% chlorhexidine gel and calcium hydroxide with propylene glycol on Candida albicans-infected root canal dentinal tubules at two different depths (200 μm and 400 μm) and two time intervals (day 1 and 7). METHODS A total of 90 extracted human teeth were sectioned below the cementoenamel junction and t...